PACMO-b-PDPA两亲性嵌段聚合物的合成及其纳米自组装  

Synthesis of amphiphilic block copolymer PACMO-b-PDPA and its self-assembly

作　　者：陈莉[1,2] 杨雪[1,2] 赵军强[1,2] 赵义平[1,2] 

机构地区：[1]天津工业大学材料科学与工程学院,天津300387 [2]天津工业大学省部共建分离膜与膜过程国家重点实验室,天津300387

出　　处：《天津工业大学学报》2017年第3期1-5,共5页Journal of Tiangong University

基　　金：国家自然科学基金资助项目(81502624)

摘　　要：为了制备pH响应型聚丙烯酰吗啉基纳米药物载体,通过两步可逆加成-断裂链转移(RAFT)活性自由基聚合方法制备了一系列具有不同PDPA链段长度的聚丙烯酰吗啉-b-2-(二异丙基氨基)乙基甲基丙烯酸酯(PACMO-b-PDPA)两亲性嵌段聚合物.采用红外光谱、核磁共振氢谱、凝胶渗透色谱等对产物的结构进行了表征;采用动态光散射、透射电镜等对聚合物在水溶液中自组装形成的纳米粒进行了表征.结果表明:该聚合物符合RAFT活性聚合的根本特征,分子质量可控且分布较窄(Mw/Mn值<1.2);自组装形成的纳米粒为均匀的球形,并且平均粒径均小于200 nm,满足纳米药物载体的粒径要求.For the preparation of pH-responsive Poly （N-acryloylmorpholine） based nano-drug carriers, a series of am-phiphilic block copolymer poly（acryloyl morpholine）-b-poly（2-（diisopropylamino）ethyl methacrylate） （termed as PACMO-CTA and PACMO-b-PDPA） with different PDPA chain length were synthesized via two-step re-versible addition fragmentation chain transfer （RAFT） polymerization. The structure of the products were char-acterized by Fourier transform infrared spectrum（FT-IR）, proton nuclear magnetic resonance （!H-NMR）spec- trometry , gel permeation chromatography（GPC）. The results showed that the molecular weight of the polymers were controlled and the molecular weight distribution was narrow （Mw/Mn 〈 1.2） in accordance with the funda-mental characteristics of RAFT active polymerization. Moreover, the nanoparticles formed by self-assembly were spherical and the average particle size were less than 200 nm, which meet the requirement of nano-drug carriers.

关 键 词：聚丙烯酰吗啉 聚2-(二异丙基氨基)乙基甲基丙烯酸酯 自组装 纳米粒 

分 类 号：TQ463[化学工程—制药化工]