双酚A的内分泌干扰效应研究进展  

Advances in endocrine disrupting effects of bisphenol A

作　　者：吴皓[1] 孙东[1] 蔡卓平[2] 刁盼盼[1] 石健[1] 陈琪[1] 段舜山[1] 

机构地区：[1]暨南大学水生生物研究中心,广州510632 [2]广东省生态学会,广州510650

出　　处：《生态科学》2017年第3期200-206,共7页Ecological Science

基　　金：广东省省级科技计划项目(2013B031100004;2015A070709013;2016A070708011);水体富营养化与赤潮防治广东普通高校重点实验室(暨南大学)(KLGHEI KLB07007);广州市科技计划项目(201609010091;201707010481)

摘　　要：双酚A(Bisphenol A,BPA)是一种危害生物体内分泌干扰效应的环境激素。近年来,随着工农业的不断发展,造纸行业、电子产品、食品包装等行业大量使用BPA,国内外主要河流、湖泊都不同程度受到了BPA的污染。BPA通过富集会影响人类激素的合成、释放、转运,进而影响人的生殖和发育。BPA的毒性效应主要包括内分泌干扰物、神经毒素、免疫毒素等方面,这些致毒效应甚至会增加细胞癌变、畸变的可能性。此外BPA毒性替代物、BPA与其他物质结合的产物都增加了BPA毒性的多样性,逐渐成为了危害人类生命安全的又一大隐患。通过研究BPA毒性效应以及近年来BPA的替代品,了解双酚A的致毒机理,为研究预防控制BPA污染对人类健康的影响提供参考依据。Bisphenol A （BPA） is an environmental hormone, which has a harmful effect to endocrine-disrupting of organism. In recent years, with the booming of industry and agriculture and extensive use of BPA in paper industry, electronics, food packaging and other industries, many foreign and domestic rivers and lakes have been polluted by BPA to some degree. BPA has played a role in human hormones of synthesis, releasing, transportation, thereby affecting the physiological behavior of human reproduction and development. Toxic effects of BPA include endocrine disruptors, neurotoxins, immunotoxins and so on. These toxic effects have a relationship to cancer cells and may even increase the possibility of distortion. In addition, BPA toxic alternatives and its combination with other substances have increased the diversity of toxicity of BPA, which becomes a risk to human life gradually. Studying the toxic effects of BPA and BPA alternatives, and having a better understanding the mechanism of toxicity of BPA are useful to prevention and control of BPA pollution on human health.

关 键 词：双酚A 内分泌 干扰效应 环境激素 

分 类 号：Q178.1[生物学—水生生物学]