Efficient synthesis of pyrano[2,3-d]pyrimidinone and pyrido[2,3-d]pyrimidine derivatives in presence of novel basic ionic liquid catalyst  

新型碱性离子液体催化剂高效催化合成吡喃酮[2,3-d]嘧啶酮和[2,3-d]嘧啶衍生物（英文）

作　　者：Omid Goli Jolodar Farhad Shirini Mohadeseh Seddighi 

机构地区：[1]桂兰大学理学院化学系

出　　处：《Chinese Journal of Catalysis》2017年第7期1245-1251,共7页催化学报（英文）

基　　金：the University of Guilan Research Council for the partial support of this work

摘　　要：A basic ionic liquid, namely 1,1＇-（butane-1,4-diyl）bis（1,4-diazabicyclo [2.2.2]octan-1-ium） hydrox-ide, was prepared and characterized using Fourier-transform infrared spectroscopy, XH nuclear magnetic resonance spectroscopy, and pH measurements. The ionic liquid was used for efficient promotion of the synthesis of pyrano[2,3-d]pyrimidinone and pyrido[2,3-d]pyrimidine derivatives at room temperature under grinding conditions. A simple procedure, short reaction time, high yields, non-column chromatographic separation, commercial availability of the starting materials, and recyclability of the catalyst are attractive features of this process.制备了碱性离子液体1,1'-(丁烷-1,4-二基)双(1,4-二氮杂二环[2.2.2]辛烷-1-ium)羟化物,并采用红外光谱、~1H核磁共振谱和pH值分析对其进行了表征.然后将它用于室温研磨条件下高效催化合成吡喃酮[2,3-d]嘧啶酮和[2,3-d]嘧啶.该法步骤简单,反应时间短,产物收率高,无需柱色谱分离,原料易得,且可回收利用.

关 键 词：Basic catalyst Multicomponent reaction Pyrimidine derivative GRINDING 

分 类 号：O626[理学—有机化学]