猪囊尾蚴半胱氨酸蛋白酶TsCL-1动态结构柔性分析研究  

Study on the Structural Flexibility of Cysteine Protease TsCL-1 from Cysticercus Cellulose

作　　者：杨琳[1,2] 朱月勋 杨艳超 赵琴平[1] 杨力权 

机构地区：[1]武汉大学基础医学院,武汉430071 [2]云南省大理白族自治州血吸虫病防治研究所,云南大理671000 [3]大理大学农学与生物科学学院,云南大理671003

出　　处：《大理大学学报》2017年第6期55-58,共4页Journal of Dali University

基　　金：大学生科研基金资助项目(KYSX201615)

摘　　要：通过对猪囊尾蚴半胱氨酸蛋白酶Ts CL-1的结构模型进行分子动力学模拟,并对其进行模拟过程中的结构稳定性和动态结构柔性分析。结果表明,模拟过程中Ts CL-1总体结构相对稳定;分子的结构骨架具有较小的波动,而分子的表面环区和底物结合区域则具有较大的波动和较强的构象柔性。研究结果将为进一步深入研究Ts CL-1的动力学行为和功能关系奠定基础。Using the Molecular Dynamics Simulation method, the dynamic structural stability and conformational flexibility of cysteine protease Ts CL-1 from Cysticercus cellulose have been investigated. The results indicate that Ts CL-1 contains an overall structural stability during the simulation. The results also indicate that the structural core of Ts CL-1 shows a small fluctuation amplitude, whereas most of the surface-exposed loops and the substrate binding sites experience significant conformational fluctuations and exhibit a highly structural flexibility. The results of this article will provide a solid basis for further studying the relationship between dynamic structural features and functions of Ts CL-1.

关 键 词：半胱氨酸蛋白酶TsCL-1 分子动力学模拟 动态结构柔性 结构功能研究 

分 类 号：Q6[生物学—生物物理学]