Cell membrane-coated nanoparticles for tumor-targeted drug delivery  

用于肿瘤靶向递药的细胞膜包覆纳米粒子（英文）

作　　者：柴芝兰 胡雪峰 陆伟跃 

机构地区：[1]Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Fudan University, Shanghai 201203, China

出　　处：《Science China Materials》2017年第6期504-510,共7页中国科学（材料科学（英文版）

基　　金：supported by the National Basic Research Program of China (2013CB932500);the National Natural Science Foundation of China (81273458 and 81473149)

摘　　要：Nanoparticles can be enriched at tumor site and improve the therapeutic efficacy of many chemother- apy drugs with the well-known enhanced permeability and retention （EPR） effect. While conventional preparations of materials for nanoscale drug delivery system mainly focused on chemical synthesis, recently the combination of synthetic carrier and natural biomimetic carrier has gained more and more attention. As a new generation of biomimetic nanoparticles, cell membrane-coated nanoparticles combine the complex biological functions of natural membranes and the physicochemical properties of synthetic nanomaterials for a more effective drug delivery. Herein, we briefly review the recent advances on cell membrane-coated nanoparticles for tumor-targeted drug delivery via the prolonging systemic circulation lifetime and the active targeting effect. Since the preferential accumulation of cell membrane-coated nanopar- ticles in tumor site, they are able to improve the therapeutic efficacy of conventional chemotherapy drugs in antitumor treatment as well as to reduce the systemic toxicity. We also introduce a systematic targeted strategy for the promising application of this platform on brain tumors.由于EPR效应,纳米粒子能够在肿瘤部位浓集并提高许多化疗药物的治疗指数.传统纳米递药系统的载体材料主要通过化学合成方法制备,而目前将化学合成载体与天然仿生载体相结合的策略得到越来越多的关注.细胞膜包覆纳米粒子作为新一代仿生纳米制剂,它将细胞膜特有的生物学功能与化学合成材料的理化性质相结合,形成更有效的递药系统.本文就细胞膜包覆纳米粒子的长循环效果及主动靶向作用在肿瘤靶向治疗中的研究进行综述,并就其在脑部肿瘤治疗中的应用前景进行了展望.

关 键 词：cell membrane biomimetic nanoparticle tumor-tar geting drug delivery 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工]