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作 者:杨子聪[1] 刘宇[1] 甘剑挺[1] 陆政德[1] 袁军[1] 施莹[1] 刘伶[1] 林英忠[1]
机构地区:[1]广西壮族自治区人民医院心内科,南宁530021
出 处:《中国临床新医学》2017年第5期403-405,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基 金:国家自然科学基金资助项目(编号:81360055);广西科学研究与技术开发计划项目(编号:桂科攻14124003-9);广西卫计委科研课题(编号:Z2014213)
摘 要:目的探讨白介素22(IL-22)与冠状动脉钙化的关系以及预测价值。方法将202例研究对象根据冠状动脉CT检查计算钙化积分结果分为低钙化积分组(LCAC,总积分≤300)146例,为非冠心病者;高钙化积分组(HCAC,总积分>300)56例,为冠心病者。通过ELISA法测定不同组别血清IL-22水平。结果LCAC组IL-22为(28.34±12.63)pg/ml,HCAC组IL-22为(38.59±12.90)pg/ml(t=-6.12,P<0.001)。相关性分析提示血清IL-22水平与冠脉钙化积分(CCS)有明显相关性(r=0.42,P<0.01)。IL-22诊断冠状动脉钙化的ROC曲线下面积为0.871,最佳临界值为27.50 pg/ml,此时敏感度为85%,特异度为71%。结论严重冠状动脉钙化者血清IL-22水平显著增高,血清IL-22可能可以作为冠状动脉钙化预测因子。Objective To investigate the correlation between serum IL-22 and coronary artery calcification and the predictive value of IL-22 in vascular calcification. Methods 202 patients were divided into low calcification group(LCAC, total scores〈300, with non-coronary heart disease, n = 146), and calcification group(HCAC, high total scores 〉 300, with coronary heart disease, n = 56). The levels of serum IL-22 were determined by ELISA. Re- suits The levels of IL-22 were (28.34 ± 12. 63 ) pg/ml in the LCAC group and ( 38.59 ± 12.90) pg/ml in the HCAC group( t = -6. 12, P 〈 0. 001 ). The statistic results showed that there was a significant correlation between the level of serum IL-22 and the coronary calcification scores ( HCAC : r = 0. 42, P 〈 O. 01 ). The area under ROC curve of IL-22 was 0. 871, and the optimal critical value was 27.50 pg/ml, with a sensitivity of 85% and a specificity of 71%. Conclusion The level of serum IL-22 is significantly increased in the patients with severe coronary artery calcification, which may be used as a predictor of coronary artery calcification.
分 类 号:R543.5[医药卫生—心血管疾病]
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