血清IL-22与冠状动脉钙化的相关性研究  

Study on the correlation between serum IL-22 and coronary artery calcification

作　　者：杨子聪[1] 刘宇[1] 甘剑挺[1] 陆政德[1] 袁军[1] 施莹[1] 刘伶[1] 林英忠[1] 

机构地区：[1]广西壮族自治区人民医院心内科,南宁530021

出　　处：《中国临床新医学》2017年第5期403-405,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家自然科学基金资助项目(编号:81360055);广西科学研究与技术开发计划项目(编号:桂科攻14124003-9);广西卫计委科研课题(编号:Z2014213)

摘　　要：目的探讨白介素22(IL-22)与冠状动脉钙化的关系以及预测价值。方法将202例研究对象根据冠状动脉CT检查计算钙化积分结果分为低钙化积分组(LCAC,总积分≤300)146例,为非冠心病者;高钙化积分组(HCAC,总积分>300)56例,为冠心病者。通过ELISA法测定不同组别血清IL-22水平。结果LCAC组IL-22为(28.34±12.63)pg/ml,HCAC组IL-22为(38.59±12.90)pg/ml(t=-6.12,P<0.001)。相关性分析提示血清IL-22水平与冠脉钙化积分(CCS)有明显相关性(r=0.42,P<0.01)。IL-22诊断冠状动脉钙化的ROC曲线下面积为0.871,最佳临界值为27.50 pg/ml,此时敏感度为85%,特异度为71%。结论严重冠状动脉钙化者血清IL-22水平显著增高,血清IL-22可能可以作为冠状动脉钙化预测因子。Objective To investigate the correlation between serum IL-22 and coronary artery calcification and the predictive value of IL-22 in vascular calcification. Methods 202 patients were divided into low calcification group（LCAC, total scores〈300, with non-coronary heart disease, n = 146）, and calcification group（HCAC, high total scores 〉 300, with coronary heart disease, n = 56）. The levels of serum IL-22 were determined by ELISA. Re- suits The levels of IL-22 were （28.34 ± 12. 63 ） pg/ml in the LCAC group and （ 38.59 ± 12.90） pg/ml in the HCAC group（ t = -6. 12, P 〈 0. 001 ）. The statistic results showed that there was a significant correlation between the level of serum IL-22 and the coronary calcification scores （ HCAC ： r = 0. 42, P 〈 O. 01 ）. The area under ROC curve of IL-22 was 0. 871, and the optimal critical value was 27.50 pg/ml, with a sensitivity of 85% and a specificity of 71%. Conclusion The level of serum IL-22 is significantly increased in the patients with severe coronary artery calcification, which may be used as a predictor of coronary artery calcification.

关 键 词：白介素22 冠状动脉钙化 

分 类 号：R543.5[医药卫生—心血管疾病]