IL-10基因-592C/A多态性与儿童过敏性紫癜的关系  

The genetic association of interleukin-10 polymorphisms with Henoch-Schonlein purpura in children

作　　者：余燕娟 张向峰[1] 常会娟[1] 靳秀红[1] 张志英[1] 张小宁[1] 

机构地区：[1]郑州市儿童医院呼吸科,河南450000

出　　处：《中国临床新医学》2017年第5期440-443,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的探讨白细胞介素10(IL-10)启动子区-592位点的单核苷酸多态性(SNP)与儿童过敏性紫癜(HSP)易感性之间的关系。方法收集100例HSP患儿和153名健康体检儿童全血标本,提取DNA,采用限制片断长度多态分析-聚合酶链反应方法(RFLP/PCR)对IL-10的基因启动子区592位点基因型进行分析,比较病例组与正常对照组的基因分布。结果 HSP患儿IL-10基因-592C/A位点等位基因频率和基因型频率与正常对照组差异无统计学意义(P>0.05)。结论 IL-10基因-592C/A多态性与儿童HSP易感性无关。Objective To analyze the relationship between -592 site A/C polymorphism in interleukin 10 （IL-10） gene and susceptibility to Henoch-Schonlein purpura（HSP） in children. Methods The whole blood speci- mens of 112 HSP patients and 153 control subjects were collected and their genomic DNAs were extracted. The IL-10 592 site gene was analyzed by restriction fragment length polymorphism/polymerase chain reaction（ RFLP/PCR）, and the allele and genotype frequencies were compared between the HSP patients and the normal subjects. Results No significant difference was found in IL-IO gene-592 C/A polymorphism between the HSP patients and the healthy con- trols（P 〉 0.05）. Conclusion IL-10 gene-592 C/A polymorphism has no association with susceptibility of HSP in children.

关 键 词：过敏性紫癜 白细胞介素10 基因多态性 儿童 

分 类 号：R729[医药卫生—儿科]