比索洛尔对左心室射血分数保留的心力衰竭患者神经内分泌因子的影响  

TEffect of Bisoprolol on Neuroendocrine Factor for Patients with Reserved Left Ventricular Ejection Fraction

作　　者：吴阿兰 苏伟青[1] 胡荣权 钟智[1] 曹秋凤[1] 刘菊花[1] 

机构地区：[1]广东省廉江市人民医院,广东廉江524400

出　　处：《中国医学创新》2017年第17期60-63,共4页Medical Innovation of China

摘　　要：目的:探析左心室射血分数保留的心力衰竭患者应用比索洛尔疗法对其神经内分泌因子的影响。方法:选择2013年6月-2016年4月本院收治的左心室射血分数保留的心力衰竭患者90例,根据随机数字表法分为对照组和观察组,每组45例,对照组进行利尿剂、醛固酮受体拮抗剂、血管紧张素Ⅱ受体拮抗剂或血管紧张素转化酶抑制剂联合治疗,观察组在此基础上加用5~10 mg/d比索洛尔,两组均治疗14 d。比较两组治疗前后的左心室射血分数(LVEF)、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、左室舒张末期内径(LVEDd)等心功能指标情况;比较两组治疗前后超敏C反应蛋白(hs-CRP)、内皮素(ET)、肿瘤坏死因子-α(TNF-α)、血栓烷B2(TXB2)、白介素-6(IL-6)、嗜铬粒蛋白A(CGA)、瘦素(LP)、心房钠尿肽(ANP)、B型尿钠肽(BNP)等神经内分泌因子水平的变化;比较两组治疗后的不良反应的发生情况。结果:观察组治疗后的LVEF、LVEDV、LVESV、LVEDd等心功能指标显著优于对照组,差异均有统计学意义(P<0.05);两组治疗后的hs-CRP、ET、TNF-α、TXB2、IL-6、CGA、LP、ANP、BNP等神经内分泌因子指标均有改善,但观察组治疗后的各项指标均显著优于对照组,差异均有统计学意义(P<0.05)。结论:左心室射血分数保留的心力衰竭患者进行比索洛尔疗法,可显著改善患者的神经内分泌因子和心功能指标水平,临床效果确切,安全性高,值得临床推广。Objective： To explore the effect of Bisoprolol on neuroendoerine factor for patients with reserved left ventricular ejection fraction.Method ： A total of 90 patients with reserved ventricular ejection fraction admitted to our hospital from June 2013 to April 2016 were selected and divided into the control group and the observation group according to random number table method, 45 cases in each group.The control group was treated by the combination of diuretics, aldosterone receptor antagonists, angiotensin ]~ receptor antagonists or angiotensin converting enzyme inhibitors.On this basis, the observation group added 5-10 mg/d Bisoprolol for treatment and both groups were treated for 14 days.The cardiac function indexes, such as left ventrieular ejection fraction （ LVEF ）, left ventricular enddiastolie volume （ LVEDV ）, left ventrieular end-systolic volume （ LVESV ）, left ventricular end-diastolic dimension （ LVEDd ）, of two groups before and after treatment were compared.The neuroendoerine cytokines changes, such as hs-CRP, ET, TNF-α, TXB2, IL-6, CGA, LP, ANP and BNP, of two groups before and after treatment were compared.The adverse reactions of two groups were compared after treatment. Result： The cardiac function indexes, such as LVEF, LVEDV, LVESV, LVEDd of the observation group were significantly better than those of the control group after treatment and the differences were statistically significant （P〈0.05） .After treatment, neuroendocrine cytokines indexes （hs-CRP, ET, TNF-α, TXB2, IL-6, CGA, LP, ANP and BNP ） of two groups were both improved, however, such euroendocrine cytokines indexes of the observation group were significantly better than those of the control group and the differences were statistically significant （P〈0.05） .Conclusion： The therapy of Bisoprolol for patients with reserved left ventricular ejection fraction can significantly improve the levels of neumendoerine factors and cardiac function indicators with accurate clinical effect and high safety

关 键 词：临床观察 神经内分泌因子 心力衰竭 比索洛尔 

分 类 号：R541.6[医药卫生—心血管疾病]