血清甘胆酸在乙型肝炎肝硬化肝细胞损害中的临床应用价值  

The Clinical Application Value about Serum Cholyglycine in Hepatitis b Cirrhosis of the Liver Cell Damage

作　　者：肖婷[1] 曾富强[1] 谢思思[1] 陈丽萍[1] 吴定昌[1] 

机构地区：[1]福建省龙岩市第一医院,福建医科大学附属龙岩第一医院检验科,364000

出　　处：《医学理论与实践》2017年第11期1576-1578,1584,共4页The Journal of Medical Theory and Practice

摘　　要：目的:探讨血清甘胆酸(Cholyglycine,CG)检测在乙型肝炎肝硬化肝细胞损害中的临床应用价值。方法:选择2016年1-10月我院消化科住院的111例患者,其中乙型肝炎肝硬化组52例,慢性乙型肝炎病毒携带者(慢性HBV携带组)59例;另选同期60例健康体检者为对照组。采用均相免疫法检测血清甘胆酸水平,探讨血清甘胆酸等指标在乙型肝炎肝硬化肝细胞损害中的临床应用价值及相关性。结果:乙型肝炎肝硬化组与慢性HBV携带组的CG、总胆汁酸(TBA)、谷氨酰转肽酶(GGT)、谷草转氨酶(AST)值均明显高于对照组(P均<0.01),其中CG升高最为显著,CG水平在乙型肝炎肝硬化组中显著高于慢性HBV携带组(χ~2=60.025,P<0.01),其ROC^(AUC)、敏感度、特异度最大,分别为0.952、90.4%、98.3%,明显高于慢性HBV携带组;两组CG与TBA、GGT均呈显著正相关(R值分别为0.835、0.407;0.726、0.440,P值均<0.01),与ALT均未见相关性(R=0.254,P=0.069;R=0.100,P=0.451)。结论:血清CG水平可用于乙型肝炎肝硬化肝细胞损害判别的重要指标之一。Objective： To investigate the serum f cbolic acid （Cholyglycine, CG） detection in hepatitis b cirrhosis of the liver cell damage in the clinical application value. Methods： Choose between January 2016 and October 2016 in longyan of fujian province during the period of the first hospital gastroenterology dept. 111 patients in hospital, including hepa- titis b cirrhosis group 52 cases;Chronic hepatitis b virus carriers （chronic HBV carry group） 59 cases; Health group of 60 cases. Homogeneous immune method is used to detect the serum bile acid level, explore the gump serum bile acid, and other biological indicator in the clinical value of hepatitis b cirrhosis of the liver cell damage and correlation. Groups compared with rank and inspection,＇ comparison between groups by ehi-square test. Results： hepatitis b cirrhosis of the liver with chronic HBV carry group, than healthy controls, CG, total bile acid （associates）, （gamma glutamyl transpeptidase） （COT）, aspertate aminotransferase （AST） values were significantly higher than that of healthy controls （P〈0.01）,of which the CG increased most significantly, it is 20.3 and 50. 1 times of the two groups after;CG levels in hepatitis b cirrhosis group, significantly higher than that in chronic HBV carriers groups （X^2= 60. 025,P〈 0.01 ）, the largest ROC^auc, sensitivity, specific degree, respectively is 0. 952, and 90. 4 %, 98. 3 %, significantly higher than that of chronic HBV carriers group;both CG and associates,（X3T patients group were significantly positive correlation （R value were 0. 835,0. 407,0. 726,0. 440,P values were 〈0.01）, there were no correlation with ALT （R=0. 254,P=0. 069;R 0. 100,P=0. 451）. Conclusion：Serum CO level can be used in hepatitis b cirrhosis of the liver cell damage criterion of one of the important indexes.

关 键 词：甘胆酸 乙型肝炎肝硬化 慢性HBV携带者 肝细胞损害 

分 类 号：R512.61[医药卫生—内科学]