APN、HCY对急性脑梗死患者颈动脉粥样硬化斑块稳定性的影响  

Relationship between the stability of carotid artherosclerosis plaque and the levels of serum adopinecUn, homocysteine in patients with acute cerebral infraction

作　　者：杨永红[1] 杨建平[1] 赵旺[1] 

机构地区：[1]重庆医科大学附属永川医院神经内科

出　　处：《重庆医学》2017年第A01期13-15,共3页Chongqing medicine

基　　金：重庆神经专委会第九届“步长杯”脑血管科学研究面上项目.

摘　　要：目的探讨急性脑梗死（ACI）患者颈动脉粥样硬化斑块稳定性与血清脂联素（APN）和同型半胱氨酸（HCY）水平的相关性。方法按颈动脉彩色多普勒超声仪检查结果将60例ACI患者分为无斑块组（15例）、稳定斑块组（20例）和不稳定斑块组（25例）。采用酶联免疫法检测ACI患者入院48h内和3个月时，以及30名健康体检者（对照组）APN和HCY水平；分析APN、HCY水平与ACI患者颈动脉粥样硬化斑块稳定性的关系。结果（1）ACI患者入院48h内和3个月时APN水平明显低于对照组，差异均有统计学意义（P〈0．05），HCY水平与对照组比较差异均无统计学意义（P〉O．05）；（2）ACI患者颈动脉斑块稳定性与APN、HCY水平均呈正相关（r=O．381、0．398，P〈O．05）。结论APN水平下降、HCY水平增高的ACI患者颈动脉粥样硬化斑块的稳定性降低。Objective To explore the relationship between the stability of carotid artherosclerosis plaque and the levels of serum adopinectin（APN） and homocysteine（HCY）in patients with acute cerebral infraction（ACI）. Methods According to the results of carotid artery color dopplar ultrasound test,60 ACI patients were divided into no plaques（NP） group（15 cases）,stable plaque（SP） group（20 cases） and unstable plaques（USP） group（25 cases）. The serum adiponeetin and homocysteine were detected by means of enzyme-linked immuno sorbent assay（ELISA） in ACI patients（at ACI onset^48 h and 3 M） and 30 normal controls（NC group）. The relationship between the stabilityof carotid artherosclerosis plaque and the levels of serum adopineetin and in homocysteine ACI patients were analyzed. Results （1）the serum adiponectin level in ACI patients after onsetS48 h and 3 M weresignificantly lower, HCY level in ACI patients were significantly higher than NC group（all P〉0.051. （2）In ACI patients, the stability of carotid plaque was positively correlated with the serum adiponectin level（r= 0. 341, P〈0.05）;and positively correlated with the homocysteine level（r=0. 398,P〈0.05）. Conclusion The stability of carotid artherosclerosis plaque is decreased in ACI patients with serum adi- ponectin level decreasing and homocysteine level increasing.

关 键 词：急性脑梗死 颈动脉粥样硬化斑块 脂联素 同型半胱氨酸 稳定性 

分 类 号：R543.4[医药卫生—心血管疾病]