注射用丹参多酚酸盐治疗急性脑梗死疗效及安全性观察  

Observation of injection with salvia miitiorrhiza polypbenols acid salt in the efficacy and safety of the treatment of acute cerebral infarction patients

作　　者：刘南暖[1] 郑永强[1] 汪健[1] 邓晓玲[1] 秦碧勇[1] 

机构地区：[1]湖北医药学院附属人民医院神经内科,十堰442000

出　　处：《重庆医学》2017年第A01期48-51,共4页Chongqing medicine

摘　　要：目的分析应用丹参多酚酸盐静脉注射治疗急性脑梗死的疗效。方法采用随机双盲试验选取该院2014年7月至2016年7月收治的急性脑梗死患者150例，均分为丹参多酚酸组和对照组。对照组应用常规药物进行治疗，而丹参多酚酸组在常规药物治疗基础上应用丹参多酚酸盐静脉注射治疗，比较治疗后两组患者整体疗效及神经状况和生活能力、不良反应等情况。结果治疗后两组患者Barthel量表评分，大脑前、中、后动脉血流速率均较治疗前显著改善，国立卫生研究院卒中量表（NIHSS）评分，全血高、低切黏度，血细胞比容均明显低于治疗前，且丹参多酚酸组患者上述指标的改善更优于对照组，丹参多酚酸组患者总有效率明显高于对照组，差异均有统计学意义（P〈O．05）。两组患者不良反应发生率比较差异无统计学意义（P〉0．05）。结论应用丹参多酚酸盐静脉注射治疗急性脑梗死疗效显著，能有效改善脑卒中患者预后及脑血流状况，且未增加各种不良反应发生率。Objective To analyze the therapeutic effect of intravenous injection of alvianolate on patients with acute cerebral infarc- tion. Methods 150 cases of patients with acute cerebral infarction were selected in our hospital from July 2014 to July 2016 were involved and they were radomly divided into salvianolate group and control group in a double blind method. The control group was given conventional treatment, the salvianolate group treated by salvianolate injection and conventional treatment. The efficacy, neural function,daily life ability and adverse reactions of two groups after treatment were compared. Results Barthel index, the mean blood velocity of the anterior cerebral artery（ACA）, middle cerebral artery（MCA）, and posterior cerebral artery（PCA） in of salvi- anolate group were significantly higher than the control group（P〈0.05）. NIHSS score,the High and low shear viscosity of whole blood, hematocrit of salvianolate group is lower than that of control group（P〈0.05）. The total effective rate of the salvianolate group was significantly higher than the control group（P〈0.05）,and the incidence of adverse reactions was significantly less than the control group（P〈0. 05）. Conclusion The efficacy of injectable salvianolate treatment of acute cerebral infarction patients was significant. It can effectively restore the patient＇s nervous system and the cerebral blood flow situation, and avoid the occurrence of various adverse reactions.

关 键 词：丹参多酚酸盐 急性脑梗死 疗效 安全性 

分 类 号：R541.4[医药卫生—心血管疾病]