活检标本胸苷激酶-1水平检测模式的建立及在消化道疾病筛查中的应用初探  

Establishment of a model for the detection of thymidine kinase-1 in biopsy specimens and primary application in the screening of digestive tract diseases

作　　者：李永余 王灿阳[1] 黄双茂 张荣君[1] 李国花[1] 

机构地区：[1]福建省晋江市医院,福建晋江362200

出　　处：《中国实验诊断学》2017年第6期986-988,共3页Chinese Journal of Laboratory Diagnosis

基　　金：福建省晋江市科技资助项目2010-3-65;泉州市卫生科技计划2011-575-11

摘　　要：目的为更好地在临床开展消化道肿瘤筛查,建立一种全新的观察模式。方法利用反应细胞增殖的特性,测定不同疾病的组织活检标本胸苷激酶1(TK1)浓度,结果经SPSS19.0统计分析。结果不同组别检测结果具有明显差异(F值17.026,P<0.001)、尤其是肿瘤组;齐化数据与血清研究比较有3-4个数量级单位改变幅度。结论可疑病例活检标本TK1检测在消化道疾病判别中展现的临床诊断意义,表明其成为一个新型、简便、快速、灵敏的早期预警模式的良好价值。Objective To better carry out the screening of digestive tract tumors,we explore the establishment of a new observation model. Methods Reflecting the degree of cell proliferation,tissue biopsy specimens of different disea- ses were determined by thymidine kinase-1 （TK1） levels,analyze the data hy SPSS19.0. Results showed that the de- tection results of different groups were significantly different （F17. 026, P〈0. 001）, especially in the tumor group; Compared with serum studies,the reduced data has increased of 10000 to 1000 times. Conclusion TK1 detection of bi opsy specimens from suspected cases is helpful to the clinical judgment of the digestive tract disease,and would become a new, simple,rapid and sensitive warning model for early cancer.

关 键 词：胸苷激酶1 活检标本 消化道疾病 

分 类 号：R446.1[医药卫生—诊断学] R57[医药卫生—临床医学]