DNJ-C-6氘代衍生物合成及生物活性测试  

Synthesis and preliminary biological evaluation of C-6 deutero DNJ

作　　者：汪文飞[1] 汪芳[2] 梁婷婷[2] 方志杰[1] 

机构地区：[1]南京理工大学化工学院,江苏南京210094 [2]南京中医药大学药学院,江苏南京210023

出　　处：《化学研究与应用》2017年第6期793-798,共6页Chemical Research and Application

摘　　要：以1-脱氧野尻霉素(DNJ)为原料,通过新设计路线合成中间体N-苄氧羰基-2,3,4,6-四-O-苄基-1-脱氧野尻霉素,并在此中间体的基础上通过氧化、氘代硼氢化钠还原,脱保护得到C-6氘代DNJ衍生物,最后考察了目标化合物对α-糖苷酶抑制活性。The key intermediate2,3,6-tri-O-benzyl-N-benzyloxycarbonyl-l,5-dideoxy-1,5-imino-D-glucitol was synthesized from natural product DNJ by new synthetic route. Then based on the intermediate,the final product C-6 deutero DNJ was synthesized through oxidation,reducing by sodium borodeuteride and eprotection.Finally,the α-glucosidase inhibitory activity of the target compound was investigated.

关 键 词：DNJ 氘代 α-糖苷酶抑制活性 

分 类 号：O629.3[理学—有机化学]