血清NT-proBNP、IL-6、TNF-α检测在肺损伤病情与预后评估中的应用价值  

The value of serum NT-proBNP,IL-6 and TNF-α in evaluation of severity and prognosis of lung injury

作　　者：洪原城[1] 洪林杰 黄种杰[1] 黄鑫成[1] 

机构地区：[1]中国人民解放军第180医院呼吸内科,福建泉州362000 [2]南方医科大学第一临床医学院,广州510515

出　　处：《国际检验医学杂志》2017年第12期1603-1605,共3页International Journal of Laboratory Medicine

基　　金：2014年南京军区科研基金课题(14MS093)

摘　　要：目的观察急性肺损伤(ALI)患者血清氨基末端B型脑钠肽前体(NT-proBNP)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)的表达情况,探讨其在肺损伤严重程度及预后评估中的价值。方法选取2015年8月至2016年8月该院收治的ALI患者76例(ALI组),另选取同期体检健康者50例作为对照组,比较两组研究对象血清中NT-proBNP、IL-6、TNF-α的表达差异,同时评估其与患者预后的关系。结果 ALI组患者血清中NT-proBNP、IL-6、TNF-α的表达水平显著高于对照组,差异有统计学意义(P<0.05);重度肺损伤患者NT-proBNP、IL-6、TNF-α水平显著高于中度肺损伤患者,而中度肺损伤患者各指标表达水平亦显著高于轻度肺损伤患者,差异有统计学意义(P<0.05);治疗期间死亡组ALI患者血清NT-proBNP、IL-6、TNF-α水平均显著高于存活组,差异有统计学意义(P<0.05)。结论血清NT-proBNP、IL-6、TNF-α的水平不仅能够有效反映肺损伤的严重程度,且对患者预后有较高的预测价值。Objective To observe the expression of N-terminal pro-brain natriuretic peptide（NT-proBNP） ,interleukin（IL）-6 and TNF（tumor necrosis factor）-α in patients with acute lung injury （ALI） , and to evaluate its value in the evaluation of severity and prognosis of lung injury. Methods A total of 76 patients with ALI treated in this hospital from August 2015 to August 2016 were enrolled in this study and 50 healthy subjects were selected as the control group. The levels of NT-proBNP, IL-6 and TNF-α in the serum of the two groups were compared and their relationship with prognosis were evaluated. Results The levels of NT-proBNP, IL-6 and TNF-α in serum of ALI group were significantly higher than those of healthy control group（P〈0. 05）. The levels of NT- proBNP,IL-6 and TNF-α in the patients with severe lung injury were significantly higher than those in the patients with moderate lung injury（P〈0. 05） ;and each index in the patients with moderate lung injury was also significantly higher than those in the pa-tients with mild lung injury（P〈0. 05）. The NT-proBNP,IL-6 and TNF-α levels of the patients with ALI in the death group were significantly different from those in the survival group（P 〈0. 05）. Conclusion The levels of serum NT-proBNP, IL-6 and TNF-acan not only reflect the severity of lung injury,but also have a high predictive value for prognosis.

关 键 词：急性肺损伤 氨基末端B型脑钠肽前体 白介素6 肿瘤坏死因子Α 

分 类 号：R446.1[医药卫生—诊断学] R563[医药卫生—临床医学]