血清免疫学指标水平与小儿支原体肺炎患儿病情严重程度的关系研究  

Correlation between IL-6,IL-10,TNF-α and disease severity of children with mycoplasma pneumoniae

作　　者：刘红伟[1] 安冀坤 马桂芹[1] 李哲敏[2] 夏冬[3] 

机构地区：[1]华北石油管理局总医院儿科,河北任丘062550 [2]华北石油管理局总医院体检部B超室,河北任丘062550 [3]华北石油管理局总医院消化科,河北任丘062550

出　　处：《国际检验医学杂志》2017年第12期1608-1610,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨小儿肺炎支原体肺炎(MPP)病情严重程度与血清白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平的关系。方法于2012年1-7月,按肺部感染评分(CIPS)选取于本院诊治的重症MPP患儿30例(重症MPP组)和轻症MPP患儿32例(轻症MPP组),以30例体检健康儿童作为对照组。检测所有受试对象支气管肺泡灌洗液(BALF)和血清IL-6、IL-10、TNF-α水平及免疫球蛋白IgA、IgM、IgG水平。治疗后,对患儿再次进行IL-6、IL-10、TNF-α水平检测,分析各指标与患儿病情严重程度的关系。结果重症MPP组BALF及血清IL-6、IL-10、TNF-α水平显著高于对照组和轻症MPP组(P<0.05);轻症MPP组BALF及血清IL-6、IL-10、TNF-α水平高于对照组(P<0.05)。各研究组BALF中IL-6、IL-10、TNF-α水平均高于血清中各指标水平(P<0.05)。治疗后,重症MPP组IL-6及TNF-α水平较治疗前下降,IL-10水平上升(P<0.05)。与对照组相比,MPP患儿血清IgM水平显著升高,IgG水平显著降低(P<0.05),IgA水平比较差异无统计学意义(P>0.05)。结论 IL-6、IL-10、TNF-α水平与MPP患儿病情严重程度具有一定的相关性,可作为MPP患者诊治的依据。Objective To study the relationship between the severity of Mycoplasma pneumoniae pneumonia（MPP） and inter- leukin（IL）-6 , IL-10, tumor necrosis factor（TNF）-α level. Methods From Jan. to Jul. 2012 , according to clinical pulmonary infection score（CPIS） ？30 children with severe MPPCsevere MPP group） and 32 children with mild MPPCmild MPP group） were enrolled and 30 healthy children were enrolled as control group）. Subjects of all groups were detected for the levels of IL-6 , IL-10, TNF-α IgA,IgM and IgG. Besides,children with MPP were also detected for the levels of IL-6 ,IL-10 and TNF-α after treatment. Results The levels of IL-6 , IL-10 and TNF-α in bronchoalveolar lavage fluid（BALF） and serum in severe MPP group were higher than those in mild MPP group and control group（P〈0. 05）. The levels of IL-6 , IL-10 and TNF-α in BALF and serum were significantly higher in mild MPP group than those in control group（P〈0. 05）. In all children,the levels of IL-6？IL-10 and TNF-a in BALF were higher than those in serum. After treatment, the levels of IL-6 and TNF-α in BALF in children with severe MPP were significantly de-creased, while that of IL-10 were increased（P 〈0. 05）. Compared with control group, the IgM level in children with MPP was in-creased significantly,and the IgG level was decreased notablely（P 〈0. 05）. Conclusion There might be significant correlation be-tween levels of cytokines IL-6 , IL-10, TNF-α and the disease severity of MPP in children patients, which could be used as the basis for the clinical diagnosis and treatment.

关 键 词：支原体肺炎 儿童 白介素-6 白介素-10 肿瘤坏死因子-α 

分 类 号：R446.6[医药卫生—诊断学] R725.6[医药卫生—临床医学]