我院辛伐他汀的临床用药分析  

Analysis of the clinical application of simvastatin in our hospital

作　　者：耿娜[1] 刘博宇[1] 刘一[1] 丁庆明[1] 冯婉玉[1] 

机构地区：[1]北京大学人民医院药剂科,北京100044

出　　处：《中国药物应用与监测》2017年第3期170-173,共4页Chinese Journal of Drug Application and Monitoring

基　　金：国家科技支撑计划子课题(2013BAI06B04)

摘　　要：目的:通过对我院门急诊辛伐他汀药物的临床使用情况进行调查和分析,促进辛伐他汀的合理应用。方法:对我院2016年7月门急诊辛伐他汀使用情况进行回顾性分析并进行合理性评价,包括患者情况、科室分布、用法用量以及合并用药(与CYP3A4酶抑制剂)。结果:门急诊共计1393例患者服用辛伐他汀,平均年龄为64.7岁,存在辛伐他汀用法用量不合理现象,4例超出说明书最大剂量,42例患者合并使用CYP3A4酶抑制剂药物(分别为胺碘酮、地尔硫卓、华法林、环孢素、克拉霉素),所占比例为3%。结论:我院辛伐他汀使用基本合理,但临床用药中也存在一些超说明书用量和不适当的合并用药情况。Objective： To investigate and analyze the clinical application of simvastatin in outpatients and emergency patients in order to improve rational drug use. Methods： The application of simvastatin in outpatients and emergency patients in July, 2016 was retrospectively analyzed including evaluation of the patient information, department distribution, usage and drug combinations （co-administration of simvastatin with CYP3A4 inhibitors）. Results： There were total 1393 outpatients and emergency patients who used simvastatin. The average age was 64.7 years old. There were some inappropriate medication problems in the prescriptions. Four patients used simvastatin with a dosage higher than the maximum recommended dosage in drug direction. A total of 42 patients （3%） were prescribed simvastatin with CYP3A4 inhibitors including amiodarone, diltiazem, warfarin, cyclosporine and clarithromycin. Conclusion： Clinical use of simvastatin in outpatients and emergency prescriptions is basically reasonable in our hospital. Strategies should be taken to avoid co-administration of simvastatin with CYP3A4 inhibitors.

关 键 词：辛伐他汀 合理用药 药物相互作用 不良反应 

分 类 号：R972.6[医药卫生—药品]