右美托咪定与利多卡因对颅内肿瘤切除术患者全麻诱导期血流动力学的影响的比较  

Comparison of Effect of Dexmedetomidine and Lidocaine on the Hemodynamics of Patients with Excision of Intracranial Tumor During the Induction Period of General Anesthesia

作　　者：王东[1] 周美霞 

机构地区：[1]内蒙古科技大学包头医学院第一附属医院麻醉科,内蒙古包头014100 [2]内蒙古鄂尔多斯市达拉特旗人民医院病理科,内蒙古鄂尔多斯014300

出　　处：《中外医疗》2017年第15期153-156,共4页China & Foreign Medical Treatment

摘　　要：目的比较右美托咪定与利多卡因对颅内肿瘤切除术患者全麻诱导期血流动力学的影响。方法方便选择2016年1—12月在包头医学院第一附属医院全麻下行择期颅内肿瘤切除术的60例患者(ASAⅠ~Ⅱ级),将其随机分为3组(n=20):右美托咪定组(D组),利多卡因组(L组);对照组(C组),分别记录三组入室时基础值(T0),诱导前(T1),气管插管即刻(T2)、插管后1 min(T3)、3 min(T4)、5 min(T5)6个时点平均动脉压(MAP)及心率(HR)的变化。结果 MAP在D组的T1(70.1±2.8)、T2(75.3±2.4)T3(72.9±2.40)与L组的T1(74.4±2.9)、T2(81±2.9)、T3(78.1±2.3)以及C组的T1(95.7±2.6)、T2(103±3.1)、T3(89.3±2.9)3个时点相比较,差异有统计学意义(P<0.05);HR在D组的T1(63.1±2.7)、T2(72.1±2.1)、T3(71±2.7)与L组T1(66±3.4)、T2(74.7±2.3)、T3(73.8±3.0)以及C组T1(82.7±3.1)、T2(87.2±2.6)、T3(79.7±.2.7)3个时点相比较,差异有统计学意义(P<0.05);MAP在D组的T1(70.1±2.8)、T2(75.3±2.4)T3(72.9±2.40)与L组的T1(74.4±2.9)、T2(81±2.9)、T3(78.1±2.3)3个时点相比较,差异有统计学意义(P<0.05);HR在D组的T1(63.1±2.7)、T2(72.1±2.1)、T3(71±2.7)与L组T1(66±3.4)、T2(74.7±2.3)、T3(73.8±3.0)3个时点相比较,差异有统计学意义(P<0.05)。结论右美托咪定和利多卡因都可有效减少行颅内肿瘤切除术患者麻醉诱导期对血流动力学引起的变化,相对于利多卡因,右美托咪定的作用效果更好。Objective To compare the effect of dexmedetomidine and lidocaine on the hemodynamics of patients with excision of intracranial tumor during the induction period of general anesthesia. Methods Convenient selection 60 cases of patients with selective excision of intracranial tumor in our hospital（ASAⅠ-Ⅱ） from January 2016 to December 2016 were selected and divided into three groups with 20 cases in each, respectively Dexmedetomidine group（D group）, lidocaine group（L group） and control group（C group）, and the basic values at admission（T0）and changes of MAP and HR before induction（T1）, at intubation（T2）, in 1 min（T3）, 3 min（T4） and 5 min（T5）after intubation were respectively recorded. Results The differences in the MAP at T1, T2 and T3 between the group D, group L and group C were statistically significant[（70.1±2.8）,（75.3±2.4）,（72.9±2.40） vs（74.4±2.9）,（81±2.9）,（78.1±2.3） vs（95.7±2.6）,（103±3.1）,（89.3±2.9）]（P〈0.05）, and the HR at T1,T2 and T3 between the group D, group L and group C were statistically significant[1（63.1±2.7）,（72.1±2.1）,（71±2.7） vs（66±3.4）,（74.7±2.3）,（73.8±3.0） vs（82.7±3.1）,（87.2±2.6）,（79.7±.2.7）], and the MAP at T1, T2 and T3 between the group D and group L were statistically significant, [（70.1±2.8）,（75.3±2.4）,（72.9±2.40） vs（74.4±2.9）,（81±2.9）,（78.1±2.3）], and the HR at T1, T2 and T3 between the group D and group L were statistically significant, [（63.1 ±2.7）,（72.1±2.1）,（71±2.7） vs（66±3.4）,（74.7±2.3）,（73.8±3.0）]（P〈0.05）. Conclusion The dexmedetomidine and lidocaine can effectively reduce the changes caused by the hemodynamics of patients with excision of intracranial tumor during the induction period of general anesthesia, and the effect of dexmedetomidine is better than that of lidocaine.

关 键 词：右美托咪定 利多卡因 颅内肿瘤切除术 麻醉诱导期 血流动力学 

分 类 号：R4[医药卫生—临床医学]