重组人角质细胞生长因子2在伤口愈合及毛发再生方面的影响  

The Effects of Recombinant Human Keratinocyte Growth Factor 2 on Wound Healing and Hair Regeneration

作　　者：马丽 喻翠云[2] 刘格莎 

机构地区：[1]成都远睿生物技术有限公司,四川成都610213 [2]南华大学药学与生物科学学院,湖南衡阳421001

出　　处：《南华大学学报（自然科学版）》2017年第2期84-89,共6页Journal of University of South China：Science and Technology

摘　　要：探寻重组人角质细胞生长因子2(rh-KGF2)和易孚(EGF为主要的药品)对SD大鼠烫伤创面愈合方面效果的差异,同时探寻重组人角质细胞生长因子2(rhKGF2)和米诺地尔在毛发再生方面效果的差异.通过建立大鼠的自身对照模型,左侧形成深Ⅱ°烫伤创面,右侧涂抹脱毛膏脱毛.通过连续4~6周,每日1次对烫伤创面和脱毛区域采用涂抹的方式对伤口给药.在此过程中对大鼠的一般状态、体重、烫伤愈合效果以及新生毛长及毛重进行观察.通过分析得出的结论为:rh-KGF2在伤口愈合方面和毛发再生方面有良好的效果.In order to explore the effects of recombinant human keratinocyte growth factor 2 （rh-KGF2） and Yi Fu （EGF） on the wound healing of SD rats,and to explore the differences between the effect of rh-KGF2 and Minoxidil on hair regeneration of SD rats,the self-control rat models were established,whose left side has a deep second degree burn wound and the right side hair was removed using depilatory creams.The wounds were constantly given different drugs every day for 4~6 weeks.During this process,the general condition,body weight,scalds in rats and the healing effects of new hair length and weight of the rats were observed and analyzed.At last,it is concluded that the recombinant human keratinocyte growth factor 2 has a good effect on wound healing and hair regeneration.

关 键 词：重组人角质细胞生长因子2 重组人表皮细胞生长因子 伤口愈合 毛发再生 

分 类 号：R965.2[医药卫生—药理学] R644[医药卫生—药学]