生长激素对卵巢储备功能下降患者IVF-ET结局的影响  

The effect of growth hormone on the IVF-ET outcome of the patients with diminished ovarian reserve

作　　者：林碎玲[1] 李雪梅[1] 刘大艳[1] 吴正中[1] 谭斯匀 

机构地区：[1]南方医科大学附属深圳市妇幼保健院生殖中心,广东深圳518017

出　　处：《中国优生与遗传杂志》2017年第6期105-106,19,共3页Chinese Journal of Birth Health & Heredity

基　　金：深圳市科技计划项目;生长激素对PCOS患者IVFET治疗结局的影响及其调节黄素化颗粒细胞分泌甾体激素的作用JCYJ2016042719145515;DHEA对卵巢储备功能低下患者颗粒细胞WNT/CTNNB1通路及IVF结果的影响JCYJ20140414145551269

摘　　要：目的探讨生长激素(GH)对卵巢储备功能下降患者在体外受精-胚胎移植(IVF-ET)周期中治疗结局的影响。方法对接受IVF-ET助孕治疗的105例卵巢储备功能下降的不孕症患者随机分为应用GH组(n=55)和未应用GH的对照组(n=50)。比较两组患者促排卵相关参数、获卵数、胚胎发育情况及妊娠结局。结果 GH组的促性腺激素(Gn)总量、Gn使用天数、HCG日内膜厚度和HCG日E2值与对照组比具有显著差异(P<0.05);GH组的获卵数、MⅡ数、2PN受精数、可利用胚胎数、优质胚胎数均显著多于对照组(P<0.05);GH组的种植率和临床妊娠率与对照组相比呈升高趋势(P>0.05)。结论卵巢储备功能低下患者中添加GH可改善卵巢反应性,提高子宫内膜容受性和胚胎质量,从而改善妊娠结局。Objective： Investigate the effect of growth hormone on the IVF-ET outcome of the patients with diminished ovarian reserve. Methods： A Total of 105 diminished ovarian reserve patients with IVF-ET treatment were randomly divided into the GH treatment group （n = 55） and without GH treatment control group （n = 50） . The parameters related to ovulation induction, the number of oocytes, embryo development and pregnancy outcomes were compared between two groups. Results： There was significant difference between GH group and the control group in the total amount of Gonadotrophin （Gn） , the number of days of Gn use, endometrial thickness and estradiol levels on the day of HCG （P〈0.05） . GH group of oocytes, M II number, the number of 2PN fertilization, the number of utilization embryos, the number of high-quality embryos were significantly higher than those in control group （P〈0.05） ; implantation rate and clinical pregnancy rate showed a increasing trend in GH group compared with the control group （P 〉 0.05） . Conclusions： Add GH in patients with diminished ovarian reserve can be improved the ovarian response, improve endometrial receptivity and embryo quality, so as to improve the outcome of pregnancy.

关 键 词：生长激素 卵巢储备功能下降 体外受精-胚胎移植 

分 类 号：R714.8[医药卫生—妇产科学]