黏液型铜绿假单胞菌临床分布与耐药性分析  

Clinical distribution and drug resistance of mucoid Pseudomonas aeruginosa

作　　者：李代昆[1] 李具琼 余雪梅[1] 蔡伟[1] 薛建江[1] LI Dai-kun LI Ju-qiong YU Xue-mei CAI Wei XUE Jian-jiang(University-Town Hospital of Chongqing Medical University, Chongqing 401331, China)

机构地区：[1]重庆医科大学附属大学城医院检验科,重庆401331

出　　处：《中华医院感染学杂志》2017年第12期2645-2648,共4页Chinese Journal of Nosocomiology

摘　　要：目的为临床合理使用抗菌药物治疗黏液型铜绿假单胞菌感染提供必要的病原学依据。方法收集医院2012年1月-2016年12月临床分离的86株黏液型铜绿假单胞菌感染病例,通过查阅病历获得患者一般资料、疾病情况、抗菌药物使用等信息,回顾性分析黏液型铜绿假单胞菌的临床分布、耐药性及疗效。结果临床送检标本共分离出黏液型铜绿假单胞菌86株,男性占72.09%,女性占27.01%;老年人占83.72%,中年人占12.79%,青年人占3.49%;肺部感染、泌尿系感染和创伤感染分别占93.02%、3.49%和3.49%;氨苄西林/舒巴坦和磺胺甲噁唑/甲氧苄啶的耐药率为98.84%、95.35%,替卡西林和替卡西林/克拉维酸的耐药率为22.09%、13.95%,哌拉西林和哌拉西林/他唑巴坦的耐药率为11.63%和10.47%;疗效显著的病例占83.72%。结论黏液型铜绿假单胞菌感染主要集中在老年男性的呼吸道感染,临床应根据药敏结果合理选用抗菌药物。OBJECTIVE To provide necessary etiological bases for reasonable clinical use of antibiotics for treatment of mucoid Pseudomonas aeruginosa infections.METHODS The patients with infections caused by 86 clinical mucoid P.aeruginosa isolates were enrolled in the study from Jan 2012 to Dec 2016,the medical records were reviewed to acquire the information such as baseline data,condition of diseases,and use of antibiotics.The clinical distribution and drug resistance of the mucoid P.aeruginosa strains and the curative effect were retrospectively analyzed.RESULTS A total of 86 strains of mucoid P.aeruginosa were isolated from clinical submitted specimens,of which 72.09 % were isolated from male patients,and 27.01% were isolated from the female patients;the elderly patients accounted for 83.72%,the middle aged for 12.79%,the young people for 3.49%.The patients with pulmonary infection accounted fro 93.02 %,the patients with urinary tract infection 3.49%%,the patients with wound infec tion 3.49%.The drug resistance rates to ampicillin sulbactam and suKamethoxazole-trimethoprim were 98.84% and 95.35%,respectively;the drug resistance rates to ticarcillin and ticarcillin-clavulanic acid were 22.09% and 13.95%,respectively;the drug resistance rates to piperacillin and piperacillin-tazobactam were 11.63% and 10.47%,respectively.The patients who achieved remarkable curative effect accounted for 83.72%.CONCLUSION The elderly male patients with respiratory tract infection are dominant among the patients with mucoid P.aeruginosa infections.It is necessary to reasonably use antibiotics based on the result of the drug susceptibility testing.

关 键 词：黏液型铜绿假单胞菌 临床分布 耐药性 疗效 

分 类 号：R378.991[医药卫生—病原生物学]