超敏C-反应蛋白和同型半胱氨酸对原发性高血压患者肺部感染后血压变异性的影响分析  

Influence of high-sensitivity C-reactive protein and homocysteine on blood pressure variability of essential hypertension patients complicated with pulmonary infections

作　　者：孙辉[1] 许勤华[1] 梁松建[1] 陈金安[1] 常振东[1] SUN Hui XU Qin-hua LIANG Song-jian CHEN Jin-an CHANG Zhen-dong(NanYang City Center Hospital, Nanyang, Henan 473000, Chin)

机构地区：[1]南阳市中心医院急诊内科,河南南阳473000

出　　处：《中华医院感染学杂志》2017年第12期2695-2697,2725,共4页Chinese Journal of Nosocomiology

基　　金：河南省自然科学基金资助项目(0511041900)

摘　　要：目的探究超敏C-反应蛋白(hs-CRP)和同型半胱氨酸(Hcy)对原发性高血压合并肺部感染患者血压变异性的影响。方法选取医院2015年2-7月收治143例原发性高血压合并肺部感染患者,根据hs-CRP含量,将患者分为低hs-CRP组及高hs-CRP组,根据Hcy含量,将患者分成Ⅰ组、Ⅱ组及Ⅲ组,分别研究各指标与血压变异性的关系。结果 143例出现肺部感染患者血培养共分离出病原菌157株,主要病原菌为肺炎链球菌、流感嗜血菌、卡他莫拉菌,分别占22.29%、19.75%、17.20%;低hs-CRP组收缩压标准差(24hSSD)及舒张压标准差(24hDSD)明显低于高hs-CRP组,差异有统计学意义(P<0.05);不同Hcy三个组间,差异均有统计学意义(P<0.05),且Ⅱ组及Ⅲ组高于Ⅰ组水平,Ⅲ组高于Ⅱ组水平,差异有统计学意义(P<0.05)。结论在原发性高血压合并肺部感染患者中,hs-CRP或Hcy含量越高,血压变异性越大,临床上可结合这两项指标指导疾病的诊断及判断治疗效果。OBJECTIVE To explore the influence of high-sensitivity C-reactie protien （hs CRP） and homocysteine （Hcy） on blood pressure variability of essential hypertension patients complicated with pulmonary infections.METHODS A total of 143 essential hypertension patients complicated with pulmonary infections who were treated in the hospital from Feb.2015 to Jul.2015 were enrolled in the study and were divided into the low hs-CRP group and the high hs-CRP group according to the content of hs-CRP and into the group Ⅰ,the group Ⅱ,and the group Ⅲ according to the content of Hcy.The relationship between the indexes and the blood pressure variability was observed.RESULTS Totally 157 strains of pathogens were isolated from blood specimens of 143 patients with pulmonary infections;Streptococcus pneumoniae,Haemophilus in fluenzae,and Moraxella catarrhalis were the major species of pathogens,accounting for 22.29 %,19.75 %,and 17.20 %,respectively.The standard deviation of systolic blood pressure （24hSSD） and standard deviation of diastolic blood pressure （24hDSD） of the low hs-CRP group were significantly lower than those of the high hs-CRP group,（P〈0.05）;there was significant difference among the three Hcy groups （P〈0.05）,the levels of the above indexes of the group Ⅱ and the group Ⅲ were significantly higher than those of the group Ⅰ,which were significantly higher in the group Ⅲ than in the group lⅡ （P〈0.05）.CONCLUSION Among the essential hypertension patients complicated with pulmonary infections,the higher the content of hs-CRP or Hcy,the greater the blood pressure variability.It is necessary for the hospital to guide the diagnosis of diseases and judge the therapeutic effect based on the two kinds of indexes.

关 键 词：超敏C-反应蛋白 同型半胱氨酸 原发性高血压 肺部感染 血压变异性 

分 类 号：R563.1[医药卫生—呼吸系统]