单纯疱疹病毒感染对房颤患者的影响分析  

Influence of herpes simplex virus infection on patients with atrial fibrillation

作　　者：李飞 贾勇 薛凌 LI Fei JIA Yong XUE Ling(The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, China)

机构地区：[1]锦州医科大学附属三院心血管内三科,辽宁锦州121000 [2]锦州医科大学附属三院检验科,辽宁锦州121000

出　　处：《中华医院感染学杂志》2017年第12期2714-2717,共4页Chinese Journal of Nosocomiology

基　　金：辽宁省教育科学"十二五"规划基金资助项目(JG15DB233)

摘　　要：目的探讨单纯疱疹病毒感染与心房颤动的关系,为临床诊治提供依据。方法选取2014年1月-2016年12月医院收治的房颤患者96例,其中阵发性房颤68例,持续性房颤28例。另选同期医院健康体检者100例为对照组;所有研究对象于清晨采集空腹血,检测HSV-1抗体和HSV-2抗体,C-反应蛋白(CRP)、胱氨酸蛋白酶抑制剂C(Cyc)和血脂指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)]。结果阵发性房颤组和持续性房颤组血清HSV-1抗体和HSV-2抗体水平均显著高于对照组(P<0.01),阵发性房颤组和持续性房颤组血清HSV-1抗体和HSV-2抗体水平比较差异无统计学意义;阵发性房颤组和持续性房颤组血清HSV-1抗体阳性率、HSV-2抗体阳性率、CRP、Cyc、TC、TG和LDL-C水平均显著高于对照组,HDL-C水平显著低于对照组(P<0.05),阵发性房颤组和持续性房颤组各指标比较差异均无统计学意义;血清HSV-1抗体和HSV-2抗体与CRP呈明显正相关性(r=0.669,P=0.012;r=0.531,P=0.018);血清HSV-1抗体和HSV-2抗体与Cyc呈明显正相关性(r=0.605,P=0.015;r=0.453,P=0.032)。结论 HSV感染可能通过炎症反应和影响血脂正常代谢等过程,直接或间接地参与房颤的形成过程。OBJECTIVE To explore the relationship between the herpes simplex virus infection and atrial fibrillation so as to provide guidance for clinical diagnosis and treatment.METHODS A total of 96 patients with atrial fibrillation who were treated in the hospital from Jan 2014 to Dec 2016 were enrolled in the study,including 68 patients with paroxysmal atrial fibrillation and 28 patients with persistent atrial fibrillation,meanwhile,100 healthy people who received physical examination were set as the control group.The fasting blood specimens were drawn from all of the study objects in the morning;the levels of HSV-1,HSV-2,C-reactive protein （CRP）,Cystatin C （Cyc）,and serum lipid parameters,including total cholesterol （TC）,triglyceride （TG）,high density lipoprotein cholesterol （HDL-C）,and low density lipoprotein cholesterol （LDL-C）,were detected.RESULTS The levels of serum HSV-1 and HSV-2 were significantly higher in the paroxysmal atrial fibrillation group and persistent atrial fibrillation group than in the control group;there was no significant difference in the level of serum HSV-1 or HSV-2 between the paroxysmal atrial fibrillation group and the persistent atrial fibrillation group.The positive rates of serum HSV-1 and HSV-2 and the levels of CRP,Cyc,TC,TG,and LDL-C were significantly higher in the paroxysmal atrial fibrillation group and persistent atrial fibrillation group than in the control group;the HDL-C level was significantly lower in the paroxysmal atrial fibrillation group and persistent atrial fibrillation group than in the control group;there was no significant difference in the above indexes between the paroxysmal atrial fibrillation group and the persistent atrial fibrillation group.The serum HSV-1 and HSV-2 were positively correlated with CRP（r=0.669,P-0.012;r=0.531,P=0.018）.The serum HSV-1 and HSV-2 was positively correlated with Cyc（r=0.605,P=0.015;r=0.453,P=0.032）.CONCLUSION The HSV infection may directly or indirectly participate in the process of formation of atria

关 键 词：单纯疱疹病毒 心房颤动 C-反应蛋白 胱氨酸蛋白酶抑制剂C 

分 类 号：R541.7[医药卫生—心血管疾病]