线粒体DNA拷贝数:一种新型的职业与环境暴露生物标志  

Mitochondrial DNA copy number:a new biomarker of occupational and environmental exposure

作　　者：王铁英[1] 李静[2] 张叶 寿勇明 李芳[1] 陆荣柱[1] 高静[2] WANG Tie-ying LI Jing ZHANG Ye SHOU Yong-ming LI Fangl LU Rong-zhu GAO Jing(Department of Preventive Medicine and Health Inspection, School of Medicine Department of Pharmacology, School of Pharmacy, Jiangsu Uuniversity, Zhenjiang, Jiangsu 212013, China Medical Center, Shanghai Chemical Industry Park, Shanghai 201507, China)

机构地区：[1]江苏大学医学院预防医学与卫生检验系,江苏镇江212013 [2]江苏大学药学院药理学系,江苏镇江212013 [3]上海化学工业园区医疗中心,上海201507

出　　处：《环境与职业医学》2017年第6期560-565,570,共7页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金(编号:81373400);中国博士后科学基金(编号:2013M540424);中国博士后科学基金特别资助(编号:2015T80513);江苏省博士后科学基金(编号:1302151c)

摘　　要：线粒体是职业和环境化学物毒效应的重要靶细胞器,线粒体相应结构和功能指标可能成为化学物暴露的早期效应标志。本文综述了外周组织线粒体DNA拷贝数(mtDNAcn)在职业和环境化学物暴露下的变化特征,苯、二甲基甲酰胺等有机溶剂及多环芳烃暴露可增加mtDNAcn,但空气颗粒物与烟草烟雾的长期暴露却又能降低mtDNAcn,因而表明mtDNAcn在不同毒物及其暴露时间和剂量下可能会出现不同的效应特征,mtDNAcn在职业和环境化学物早期危害效应监护中的作用值得研究。Mitochondria is the common poison target of environmental and occupational chemicals, and related mitochondrial functional and structural changes may become early markers of chemical exposures. In this review, the variations of peripheral mitochondrial DNA copy number （mtDNAcn） were assessed after exposure to environmental and occupational chemicals, mtDNAcn was increased after exposure to chemicals such as benzene, dimethylformamide, and polycyclic aromatic hydrocarbons. However, a long-term exposure to air particles or tobacco smoke led to a decrease of mtDNAcn. Thus, mtDNAcn responses would differ depending on chemicals, exposure time, and ＂exposure dose. The application of mtDNAcn to surveillance of early effects of occupational and environmental chemicals is worth investigating.

关 键 词：线粒体 DNA拷贝数 化学物 暴露 生物标志 

分 类 号：R12[医药卫生—环境卫生学]