α-硫辛酸对2型糖尿病患者认知功能的影响  

Effects of α lipoic acid on the cognitive function of patients with type 2 diabetes mellitus

作　　者：郭梦圆 梁琛[2] 张璞[3] 李伟 GUO Mengyuan LIANG Chen ZHANG Pu LI Wei(Grade 2014, Postgraduate School, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China Department of Endocrinology, People′s Hospital of Suining County, Xuzhou, Jiangsu 221200 Department of Hematology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009 Department of Endocrinology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002)

机构地区：[1]徐州医科大学研究生学院2014级,江苏徐州221002 [2]睢宁县人民医院内分泌科,江苏睢宁221200 [3]徐州市中心医院血液科,江苏徐州221009 [4]徐州医科大学附属医院内分泌科,江苏徐州221002

出　　处：《徐州医科大学学报》2017年第6期381-383,共3页Journal of Xuzhou Medical University

基　　金：基金项目：江苏省高校自然科学基金（14KJB320027）

摘　　要：目的 探讨α-硫辛酸对2型糖尿病患者认知功能的影响。方法 2型糖尿病患者140例，按有无应用α-硫辛酸治疗分配在 A 组（70例，糖尿病一般治疗）和 B 组（70例，糖尿病一般治疗基础上每天静脉使用α-硫辛酸）中，使用蒙特利尔认知评估量表（MoCA）分别对2组患者在住院治疗前和治疗结束后30天进行认知功能评估。结果 治疗前，A组患者的认知功能评分平均为23.93±3.45，B组患者的认知功能评分平均为24.90±3.66，2组认知评分的差异无统计学意义（P〉0.05）；治疗结束后A组患者的认知功能评分平均为22.91±3.74，B组患者的认知功能评分平均26.77±2.27，B组患者的认知功能评分明显高于A组（P〈0.05）。结论 α-硫辛酸对2型糖尿病患者认知功能有保护作用。Objective To investigate the effects of α-lipoic acid on the cognitive function of patients with type 2 diabetes mellitus. Methods A total of 140 patients with type 2 diabetes mellitus were divided into two groups, according to their treatment with or without α-lipoic acid. Patients in Group A （n=70） received conventional diabetic therapy, while those in Group B （n=70） were intravenously injected with α-lipoic acid daily in addition to conventional diabetes therapy. Then, the Montreal cognitive assessment （MoCA） was performed to evaluate the cognitive function of these patients before and 30 days after treatment. Results Before treatment, the cognitive function score of Group A was （23.93±3.45） on average, while the average cognitive function score of Group B was （24.90±3.66）, which were not significant different between the two groups （P〉0.05）. After treatment, the cognitive function score of Group A was （22.91±3.74） on average, which was significantly lower than the average cognitive function score of Group B （26.77±2.27）. Conclusions α-Lipoic acid has a protective effect on the cognitive function of patients with type 2 diabetes mellitus.

关 键 词：Α-硫辛酸 2型糖尿病 蒙特利尔认知评估量表 认知功能障碍 

分 类 号：R587.1[医药卫生—内分泌]