丝氨酸蛋白酶在昆虫先天免疫中的功能和作用机制研究进展  

Advances in Functions and Action Mechanism of Serine Protease in Insect Innate Immunity

作　　者：唐琦[1] 周倩[1] 邱立鹏[1] 李东[1] 李国辉[1] Tang Qi Zhou Qian Qiu Lipeng Li Dong Li Guohui(Institute of Life Sciences, Jiangsu University, Zhenjiang Jiangsu 212013, China)

机构地区：[1]江苏大学生命科学研究院,江苏镇江212013

出　　处：《蚕业科学》2017年第3期502-508,共7页ACTA SERICOLOGICA SINICA

基　　金：国家自然科学基金项目(No.31402016;81402840);江苏大学高级人才启动基金项目(No.14JDG026);中国博士后基金项目(No.2015M571675)

摘　　要：昆虫先天免疫系统包括细胞免疫和体液免疫。细胞免疫主要通过昆虫血液中的浆细胞对入侵的微生物进行吞噬;体液免疫比较复杂,涉及到昆虫体内许多蛋白质之间的相互作用,其中丝氨酸蛋白酶及其同源物与血淋巴黑化和抗菌肽合成等过程密切相关,如参与胞内酚氧化酶原及Toll免疫信号途径的激活等,因而在昆虫的体液免疫中发挥着重要作用。本文就昆虫丝氨酸蛋白酶及其同源物的类型、结构与功能以及家蚕丝氨酸蛋白酶的研究进展进行综述,为促进家蚕、蜜蜂等经济昆虫先天免疫的分子机制研究提供参考。Insect innate immune system includes cellular immunity and humoral immunity. Cellular immunity mainly uses blood plasma cells of insects to engulf invading microbes. Humoral immunity involves complicated interactions between multiple proteins in insects. Serine proteases and their homologues play important roles in insect humoral immunity for their close relationship with hemolymph melanization and antibacterial peptide synthesis. For instances,they participate activation of intracellular prophenoloxidase and activation of Toll immune pathway. This review summarizes research progress in types,structures and functions of insect serine proteases and their homologues in silkworm（ Bombyx mori）,which will provide good references for further studies on molecular mechanism of innate immunity in silkworm,honey bee and other economic insects.

关 键 词：昆虫 丝氨酸蛋白酶 分子结构 功能 先天免疫 家蚕 

分 类 号：Q966[生物学—昆虫学] S881.2[农业科学—特种经济动物饲养]