COX-2抑制剂与丙泊酚抗肿瘤作用研究进展  

The anti-tumor effect of COX-2 inhibitor and propofol： the current evidence and research progress

作　　者：杨陈祎 王海云[1] Yang Chenyi Wang Haiyun(Department of Anesthesiology, Third Central Hospital of Tianjin, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Research Centre of The Ministry of Health, the Third Central Clinical College of Tianfin Medical University, Tianjin 300170, China)

机构地区：[1]天津市人工细胞重点实验室卫生部人工细胞工程技术研究中心天津医科大学三中心临床学院天津市第三中心医院麻醉科,天津300170

出　　处：《中国医师杂志》2017年第6期949-952,共4页Journal of Chinese Physician

基　　金：国家自然科学基金资助项目（81071059,81100984,81571054）;天津市应用基础与前沿技术研究计划（一般项目）（15JcYBJc25600）

摘　　要：环氧酶2（COX-2）抑制肿瘤细胞凋亡、引起免疫逃避。非甾体抗炎药（NSAIDs）作为常见的COX-2选择性抑制剂，是肿瘤患者多模式镇痛不可缺少的环节。丙泊酚具有抑制COX-2的抗肿瘤作用，引发国内外学者关注。本文联系COX-2抑制剂抗肿瘤作用机制，探讨丙泊酚在肿瘤围手术期麻醉中应用价值，为实现“精准麻醉”提供新的参考依据。Cyclooxygenase-2 （COX-2） could inhibit apoptosis, promote tumor cell immune escape and cause tumor angiogenesis. As a common COX-2 inhibitor, non-selective non-steroidal anti-inflammatory drugs （NSAIDs） can inhibit immune evasion, and it is an indispensable part of postoperative multimodal analgesia for tumor patients. The anti-tumor effect of propofol arouses interest in various researching area. The present review is to introduce the role of COX-2 and its inhibitors in the metastasis and recurrence of cancer, and discuss the value of propofol in tumor treatment, which is of great benefit to meet the needs of perioperative precise anesthesia.

关 键 词：环氧化酶2抑制剂/药理学 二异丙酚/药理学 肿瘤 综述 

分 类 号：R614[医药卫生—麻醉学] R730.56[医药卫生—外科学]