超声造影半定量方法评估斑块内新生血管与斑块狭窄程度及C反应蛋白的关系研究  

Relationship between intraplaque neovascularization(IPN) degree of carotid atherosclerosis determined by semi-quantitative method of contrast-enhanced ultrasound(CEUS) and the stenosis and the level of serum C-reactive protein(CRP)

作　　者：郑军[1] 何晨晖 徐翠霞[1] ZHENG Jun HE Chenhui XU Cuixia(Department of Ultrasound, the People＇s of Guyuan City, Guyuan, Ningxia756000 , Chin)

机构地区：[1]宁夏固原市人民医院,宁夏固原756000

出　　处：《宁夏医学杂志》2017年第6期522-524,共3页Ningxia Medical Journal

摘　　要：目的通过超声造影(CEUS)半定量方法评估颈动脉斑块内新生血管(IPN),探讨斑块内新生血管增强程度与狭窄程度及C反应蛋白(CRP)的关系。方法收集134例颈动脉斑块患者,均行颈动脉超声检查及颈动脉超声造影。颈动脉超声检查后根据斑块致管腔狭窄程度分为<50%组,50%~69%组,70%~99%组。造影后斑块内新生血管根据视觉上斑块内微泡进行分级:G0,斑块内没有微泡进入;G1,微泡进入到斑块的肩部和(或)外侧壁;G2,大量的微泡进入到斑块内。分析不同狭窄程度患者颈动脉斑块内新生血管增强程度分级,斑块内新生血管与CRP的关系。结果不同狭窄程度斑块内新生血管增强程度分级差异有统计学意义(P<0.05),两两组间比较差异有统计学意义(<50%组和50~69%组,P<0.05;<50%组和70~99%组,P<0.05;50~69%组和70~99%组,P<0.05)。斑块厚度与增强程度分级间呈正相关性(r=0.641,P<0.05),3组间比较CRP差异有统计学意义(P<0.05)。斑块内新生血管不同增强程度分级间比较,斑块内新生血管增强程度越高、CRP值就越高,且组间比较差异有统计学意义;相关性分析显示,斑块内新生血管增强程度与CRP有显著相关性(r=0.502,P<0.05)。结论超声造影半定量方法所评估的斑块内新生血管与斑块的狭窄严重程度有关,并与CRP呈正相关性,提示斑块狭窄程度越重、斑块内新生血管越丰富,斑块内新生血管越丰富、炎症越厉害,斑块越容易成为易损性斑块。Objective To Assess the intraplaque neovascularization（IPN） by semi -quantitative method of contrast -enhanced ultrasound（CEUS） and explore the relationship between the IPN and the stenosis and the level of serum C - reactive protein （CRP）. Methods A total of 134 cases with carotid artery plaque. All the patients underwent the standard ultrasound and CEUS. the patients were divided into three groups based on the stenosis, they are 〈 50% group ,50 - 69% group,70 -99% group. IPN was identified by rap- id movement of echogenie reflectors of mierobubbles within the plaque and graded as GO, no microbubbles in the plaque ; G1, moderate mierobubbles confined to the shoulder and/or adventitial side of the plaque ; G2, extensive microbubbles throughout the plaque. Analysis the relationship between the IPN and the stenosis and the level of serum C - reactive protein. Results There are significant differences of the degree of plaque enhancement in the three groups of different stenosises（ P 〈 0.05 ） , there are also significant differences between the two groups（ 〈50% group and 50 -69% group：P 〈0.05; 〈50% group and 70 -99% group：P 〈0.05;50 -69% group and 70 99% group ：P 〈 0.05 ）. There was positive correlation between plaque thickness and the grade of plaque enhancement （r = 0. 641, P 〈 0.05 ）. The level of serum CRP were different among the three groups and there were significant difference among the three groups（ F = 23. 793 ,P 〈0.05 ）. The higher of the grade of the plaque enhancement,the higher of the level CRP and there was significant difference between these groups. There was positive correlation between the neovascularization and the level of serum CRP （ r = 0.502, P 〈 0.05 ）. Conclusion There are positive correlation between the neovascularization of carotid atherosclerosis determined by contrast - enhanced ultrasound and the severity of stenosis and the level of serum CRP. This is suggesting that the severitier of the stenosis is, the richer of IPN is. If t

关 键 词：斑块 新生血管 狭窄 C反应蛋白 易损性 

分 类 号：R543[医药卫生—心血管疾病]