子痫前期患者生化指标改变对妊娠结局的影响  

Effect of biochemical markers changes on pregnancy outcomes in patients with preeclampsia

作　　者：宫辉[1] 阮红杰[2] 

机构地区：[1]南京市妇幼保健院检验科,江苏南京210004 [2]南京市妇幼保健院检验科门诊,江苏南京210004

出　　处：《中国卫生检验杂志》2017年第11期1592-1594,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨子痫前期患者各项生化指标的变化和临床意义,分析子痫前期患者的妊娠结局。方法选取116例子痫前期患者孕妇为研究组和116例正常孕妇作为对照组。分别检测2组孕妇ALT、AST、GGT、AKP、CK、LDH、α-HBDH、TP、ALB、TBIL、DBIL、BUN、Scr、UA。结果 2组GGT活性和TBIL、DBIL、BUN水平差异无统计学意义(P>0.05)。与对照组相比,研究组患者血清ALT、AST、AKP、CK、LDH、α-HBDH活性和Scr、UA水平均明显升高,血清TP、ALB水平均明显降低,差异均有统计学意义(P<0.05)。研究组早产、产后出血、胎盘前置等不良妊娠结局的发生率高于对照组,差异有统计学意义(P<0.05)。结论与同期正常孕妇相比,子痫前期患者孕妇部分生化指标发生明显变化。因此应严密监测子痫前期患者各项生化指标的变化,并对其进行及时有效处理和治疗,以获得良好的妊娠结局。Objective To investigate the changes and clinical significance of biochemical markers in preeclampsia patients and the pregnancy outcomes of them. Methods 116 pregnant women with preeclampsia were selected as the study group, and 116 normal pregnant women were selected as the controls. ALT, AST, GGT, AKP, CK, LDH, α - HBDH, TP, ALB, TBIL, DBIL and BUN, Scr, and UA of the 2 groups were measured. Results There was no statistical significance on the difference in GGT activity and TBIL, DBIL, BUN levels between the two groups（ P 〉 0.05）. The levels of serum ALT, AST, AKP, CK, LDH, α- HBDH and Ser, UA were significantly higher in the patients with preeclampsia than those in the control group, while serum TP, ALB levels were significantly lower in the study group, with the differences statistically significant（ P 〈 0.05 ）. Compared with the control group, the incidences of adverse pregnancy outcomes such as preterm delivery, postpartum hemorrhage, and placenta previa were also higher in women with preeclampsia, with the differences statistically significant（ P 〈 0.05 ）. Conclusion Compared with the normal healthy pregnant women, the biochemical indexes of pregnant women with preeclampsia significantly changed. Therefore, we should closely monitor the changes of biochemical indexes in patients with preeclampsia in order to treat them timely and get good pregnancy outcomes.

关 键 词：子痫前期 生化指标 妊娠结局 

分 类 号：R714.24[医药卫生—妇产科学]