晚期食管鳞癌一线化疗的疗效与血清低密度脂蛋白水平的回顾性分析  

Relationship between the effect of the first-line chemotherapy on advanced esophageal squamous cell carcinoma patients and LDL-C level

作　　者：蔡亚飞[1] 陆士新[1] 张伟杰[1] 王留兴[1] 

机构地区：[1]郑州大学第一附属医院肿瘤内科,450052

出　　处：《中国实用医刊》2017年第11期1-3,共3页Chinese Journal of Practical Medicine

摘　　要：目的 分析晚期食管鳞癌一线化疗的客观反应率及无进展生存期与治疗前患者血清低密度脂蛋白水平之间的关系.方法 选择2012 年1月至2015年12月组织病理学确诊为食管鳞状细胞癌且临床分期为Ⅲ-Ⅳ期的患者共64例,患者的一线化疗方案均为顺铂联合氟尿嘧啶.统计患者化疗前血清低密度脂蛋白水平、化疗的客观反应率和无进展生存期,采用t检验、x2检验和 Kaplan-Meier法对数据进行分析处理.结果 64例患者中血清低密度脂蛋白高于正常上限值28例,正常36例.低密度脂蛋白升高组客观反应率为17.9%,中位无进展生存期为7.1个月.正常组客观反应率为38.8%,中位无进展生存期为9.0个月.两组客观反应率比较差异未见统计学意义（P〉0.05）,无进展生存期比较差异有统计学意义（P〈0.05）.结论 血清低密度脂蛋白升高组的晚期食管鳞癌患者在一线化疗上的客观反应率及无进展生存期均低于正常组.Objective To analyze the relationship between the effect of the first-line chemotherapy on advanced esophageal squamous cell carcinoma patients and LDL-C level.Methods Sixty-four patients confirmed advanced esophageal squamous cell carcinoma from January 2012 to December 2015 were analyzed.The first-line chemotherapy were fluorouracil plus cisplatin.CLC-C level was detected before treatment begins.ORR and PFS were analyzed using T test and chi-square test and Kaplan-Meier method.Results There was 28 cases with the level of CLC-C higher than the upper limit, normal in 36 cases.The ORR and PFS were 17.9% and 7.1 months in high CLC-C level team;with the ORR and PFS were 38.8% and 9.0 months in normal team.ORR between the two groups had no significant difference （P〉0.05）, PFS was significant （P〈0.05）.Conclusions Higher LDL-C has close correlation with poor ORR and PFS in advanced esophageal squamous cell carcinomas patients.

关 键 词：低密度脂蛋白 食管鳞状细胞癌 晚期 客观反应率 无进展生存期 

分 类 号：R735.1[医药卫生—肿瘤]