An evolving function of DNA-containing exosomes in chemotherapy-induced immune response  

作　　者：Paul Kurywchak Raghu Kalluri 

出　　处：《Cell Research》2017年第6期722-723,共2页细胞研究（英文版）

摘　　要：Chemotherapy is a predominant strategy to treat cancer and is of- ten associated with toxicities like severe diarrhea that puts patients at additional risk and can hinder treatment strategies. Lian et aL recently explored the immune-mediated mechanisms of Irinotecan-induced di- arrhea in colorectal cancer and found that double-stranded DNA in small vesicles can launch inflammation pathways in immune cells through the cytosolic DNA sensor AIM2.

关 键 词：DNA传感器 免疫反应 化疗 进化 双链DNA 免疫细胞 副作用 大肠癌 

分 类 号：S852.4[农业科学—基础兽医学] TP212.3[农业科学—兽医学]