高迁移率蛋白B1介导Toll样受体信号通路的研究进展  

Updates on the Pathways of Toll-Like Receptors Mediated by HMGB1

作　　者：王方平[1] 张平安[1] 杨晓燕[1] 

机构地区：[1]武汉大学人民医院检验科,武汉430060

出　　处：《现代检验医学杂志》2017年第3期162-164,共3页Journal of Modern Laboratory Medicine

摘　　要：高迁移率族蛋白B1(high mobility group box 1 protein,HMGB1)是核内一类非组蛋白DNA结合蛋白,属于损伤相关分子模式(damage-associated molecular patterns,DAMPs),参与DNA复制、重组、修复和基因转录调控等。HMGB1能通过Toll样受体(Toll-like receptor,TLR)等激活固有免疫以及诱导T细胞分化成熟启动适应性免疫应答,与多种自身免疫性疾病、炎症性疾病和肿瘤等关系密切。目前关于HMGB1介导TLR信号通路在某些疾病中的作用的研究较多,HMGB1介导Toll样受体信号通路参与多种病理过程具有广阔的临床前景。High mobility group box 1 protein,a kind of damage-associated molecular patterns,is a group of nonhistone DNA- binding protein in the nuclear. It not only involves in DNA replication, recombination, repair, regulation of gene transcription,but also induces activation of innate immunity and T cell generation and activates the adaptive immune response through Toll-like receptor. It is also more closely related to autoimmune diseases,inflammatory diseases, tumors and so on. Currently there are many researches on the role of TLR-mediated HMGB1 signaling pathway in diseases, which is involved in a variety of pathological processes and has a broad clinical outlook.

关 键 词：高迁移率蛋白B1 TOLL样受体 信号通路 

分 类 号：R392.1[医药卫生—免疫学]