2012年寿光市自然人群慢性乙肝病毒感染者临床诊断分型及HBV-DNA、ALT分布  

Clinical diagnostic classification of chronic hepatitis B virus infection and distribution of HBV-DNA and ALT in the natural population,Shouguang city,2012

作　　者：单敏[1] 张会青[1] 王晓琼[1] 任坤岭 刘中芹 

机构地区：[1]寿光市疾病预防控制中心,山东寿光262700

出　　处：《预防医学论坛》2017年第4期241-243,共3页Preventive Medicine Tribune

基　　金：国家科技重大专项艾滋病和病毒性肝炎等重大传染病防治专项"山东省乙型病毒性肝炎防治综合示范区规模化现场流行病学和干预研究"(2009ZX10002-028)

摘　　要：目的掌握自然人群慢性HBV感染者临床诊断分型及乙型肝炎病毒脱氧核糖核酸(HBV-DNA)、丙氨酸氨基转移酶(ALT)分布特征,为实施干预提供科学依据。方法 2012年对寿光市自然人群HBV感染基线调查发现的乙肝表面抗原阳性者进行体检,依据血清学、临床、B超、病史等检查结果进行临床诊断。结果 1 902例感染者,临床诊断分型为携带者占66.72%、慢性乙肝占31.81%、肝硬化占0.94%、疑似肝癌占0.53%,临床分型与性别有关,差异有统计学意义(P<0.01);HBV-DNA>500拷贝/ml的阳性率为55.15%,ALT>40u/L的异常率为25.87%,两项指标男性均高于女性(P<0.01),且年龄分布也存在明显差异(P<0.01);感染者适应抗病毒治疗率为30.65%。结论自然人群中慢性HBV感染者以携带者为主,部分感染者HBV-DNA、ALT水平较高,适应抗病毒治疗。Objective To master the clinical diagnosis classification and the distribution characteristics of deoxyribonucleic acid of hepatitis B virus （HBV-DNA） and Alanine transaminase （ALT） of chronic HBV infection in the natural population of Shouguang city,so as to provide scientific basis for the intervention. Methods In 2012,physical examination was conducted among HBsAg-positive patients found in the HBV infection baseline survey in the natural population, and clinical diagnosis was made on the basis of serological, clinical, type-B ultrasonic and medical history, etc. Results In 1 902 cases of infection,clinical diagnosis of hepatitis B carriers accounted for 66.72%, 31.81% of chronic hepatitis B, 0.94 % of cirrhosis,0.53 % of suspected liver cancer, Clinical classification was related to gender, and the difference was statistically significant（ P 〈0.05） ;in HBV-DNA D 500 copy/ml, the positive rate was 55.10%, in ALT D 40 u/L, the abnormal rate was 25.87% ,the indexes in males were higher than those of females（ P 〈0.01）. The two indexes among the age groups were significantly different（ P〈0.01）. The rate of adaptation to antiviral treatment was 30. 65%. Con- elusion Chronic HBV infection are mainly carriers in the natural population, HBV-DNA and ALT levels are higher in some of them,who are adapt to antiviral therapy.

关 键 词：乙型肝炎 慢性 乙型肝炎病毒脱氧核糖核酸 丙氨酸氨基转移酶 

分 类 号：R512.62[医药卫生—内科学]