氧分压对急性肺动脉栓塞的诊断价值  

Value of oxygen partial pressure in the diagnosis of acute pulmonary embolism

作　　者：丁玉娇[1] 陈阳[1] 

机构地区：[1]皖南医学院法医病理学教研室,安徽芜湖241002

出　　处：《海南医学院学报》2017年第9期1172-1174,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(11221022)~~

摘　　要：目的:通过采取家兔耳缘静脉血制作自体血栓,制作家兔肺动脉栓塞模型,学习利用自体血栓建立急性肺动脉栓塞模型的方法以及探讨氧分压对急性肺动脉栓塞的诊断价值。方法:采用家兔自体血栓制作肺动脉栓塞模型,将20只家兔随机分为正常组(5只通过采取家兔耳缘静),造模后7h组(5只),造模后24h组(5只),造模后1 W组(5只)。分别于造模后7、24h、1 W抽取家兔颈动脉血,进行动脉血气分析。结果:正常组氧分压(93.15±2.26)mmHg,7h组氧分压(81.98±1.94)mmHg,24h组氧分压(84.55±2.18)mmHg,1 W组氧分压(92.66±1.92)mmHg。正常组氧分压与7h组、24h组氧分压相比,差异均有统计学意义(P<0.01)。正常组氧分压与1周组氧分压相比,差异无统计学意义(P>0.05)。结论:氧分压在急性肺动脉栓塞模型建立成功后7h已经降低,并在24h内未能恢复正常,1周后随着时间的的推移,栓子开始溶解,呼吸循环系统重新建立,氧分压逐渐恢复至正常水平。说明氧分压与急性肺动脉栓塞之间存在一定的正相关关系。Objective：To explore the value of oxygen partial pressure in the diagnosis of acute pulmonary embolism with rabbit model of pulmonary embolism.Methods：Rabbit autologous blood clots pulmonary embolism model were used in this study,and 20 rabbits were randomly divided into normal group（only by taking blood from the rabbit ear margin,n=5）,7hafter model establishment group（n=5）,（5）24hafter model establishment group（n=5）,1week after model establishment group（n=5）.7h,24 hand 1week after model establishment blood were taken from each group for arterial blood gas analysis.Results：Oxygen partial pressure was（93.15±2.26）mmHg in the normal group,（81.98±1.94）mmHg 7hafter model establishment group,and（84.55±2.18）mmHg in the 24 hafter model establishment group,and（92.66±1.92）mmHg1week after model establishment group.Significant differences were observed between the normal control group and 7hafter model establishment group and 24 hafter model establishment group（P〈0.01）.But no significant difference was observed between the normal control group and the 1week after model establishment group（P〈0.05）.Conclusion：The oxygen partial pressure starts to decrease 7hafter model establishment and will not restore to the normal level 24 hafter the model establishment.But 1 week after model the establishment embolus begins to dissolve,respiratory system are rebuilt,oxygen partial pressure gradually returned to the normal levels.These results indicate that oxygen partial pressure is positively related to acute pulmonary embolism.

关 键 词：自体血栓 肺动脉栓塞 氧分压 血气分析 

分 类 号：R89[医药卫生—法医学]