利多卡因注射液联合罗哌卡因注射液对断指再植术的麻醉疗效  

Anesthetic efficacy of lidocaine injection combined with ropivacaine injection in the treatment of digital replantation

作　　者：柯超群[1] 黄志斌[1] 汤昌明[2] 林慧卿[2] 吴寿和 KE Chao - qun HUANG Zhi - bin TANG Chang - ming LIN Hui - qing WU Shou - he(Department of Anesthesia, Fujian Provincial Hospital, Fuzhou 350001, China Department of Anesthesia, The Second People＇s Hospital Affiliated of Fujian University of Traditional Chinese Medicine, The Second People＇ s Hospital of Fujian Province, Fuzhou 350003, China Department of Anesthesia, Lecong Hospital Affiliated to Guangzhou Medical University, Foshan 528000 , Guangdong Province, China)

机构地区：[1]福建省立医院麻醉科,福州350001 [2]福建中医药大学附属第二人民医院福建省第二人民医院麻醉科,福州350003 [3]广州医科大学附属乐从医院麻醉科,广州佛山528000

出　　处：《中国临床药理学杂志》2017年第12期1123-1126,共4页The Chinese Journal of Clinical Pharmacology

基　　金：佛山市医学类科技攻关基金资助项目(20151021030016)

摘　　要：目的观察利多卡因注射液联合罗哌卡因注射液对断指再植术的麻醉疗效与安全性。方法将72例进行断指再植手术患者随机分为对照组36例和试验组36例。对照组予以罗哌卡因注射液10 mL,上肢静脉注射;试验组在对照组治疗的基础上,予以利多卡因注射液10 mL,上肢静脉注射。比较2组患者的麻醉效果、C反应蛋白(CRP)和药物不良反应的发生情况。结果试验组和对照组的麻醉效果Ⅰ级分别为97.22%(35/36例)和83.33%(30/36例),差异有统计学意义(P<0.05)。术后1,3 d,试验组的CRP分别为(7.25±1.07),(7.14±0.96)mg·L^(-1),对照组的CRP分别为(8.12±1.18),(7.90±1.01)mg·L^(-1),差异均有统计学意义(均P<0.05)。试验组的药物不良反应主要有肢动和皮肤潮红,对照组的药物不良反应主要有肢动、皮肤潮红和皮肤瘙痒。试验组和对照组的药物不良反应发生率分别为5.56%和22.22%,差异有统计学意义(P<0.05)。结论利多卡因注射液联合罗哌卡因注射液对断指再植术有较好的麻醉效果,且安全性较高。Objective To observe the anesthetic efficacy and safety of lidocaine injection combined with ropivacaine injection in the treatment of digital replantation. Methods Seventy-two patients underwent replantation were randomly divided into control group（n = 36 cases） and treatment group（n = 36 cases）. Control group was given ropivacaine injection10 mL with upper limb vein injection. Treatment group received lidocaine injection 10 mL with upper limb vein injection,on the basis of control group. The anesthetic effect,C reactive protein（CRP） and adverse drug reactions were compared between the two groups. Results The proportion of anesthesia effect of grade Ⅰin treatment and control groups were97. 22%（35/36 cases） and 83. 33%（30/36 cases） with significant difference（P〈0. 05）. After operation 1,3 d,the levels of CRP in treatment group were（7. 25 ± 1. 07）,（7. 14 ± 0. 96） mg·L^-1,which in control group were（8. 12 ± 1. 18）,（7. 90 ± 1. 01） mg ·L^-1with significant difference（P〈0. 05）. The main adverse drug reactions in treatment group were based on limb movement and skin flushing,which in control group were based on limb,skin flushing and skin itching. The incidences of adverse drug reactions in treatment and control groups were 5. 56%and 22. 22% with significant difference（P〈0. 05）. Conclusion Lidocaine injection combined with ropivacaine injection has a definitive anesthetic efficacy and safety in the treatment of digital replantation.

关 键 词：罗哌卡因注射液 利多卡因注射液 断指再植术 麻醉效果 安全性 

分 类 号：R971.2[医药卫生—药品]