蛋白磷酸酶在抗病毒天然免疫应答中的调控作用  

Role of protein phosphatase in regulating antiviral innate immune response

作　　者：张赟恺 周庆卿 陈祥[1] 刘星光[1] 

机构地区：[1]第二军医大学免疫学研究所暨医学免疫学国家重点实验室,上海200433

出　　处：《第二军医大学学报》2017年第6期769-773,共5页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81422021)~~

摘　　要：真核细胞中蛋白磷酸酶(protein phosphatase)参与细胞分裂、凋亡,调控细胞周期,参与许多信号转导过程并发挥重要生物学功能。在天然免疫应答中,当病毒入侵机体后,多种蛋白磷酸酶能够通过控制其中关键蛋白的磷酸化水平,调控抗病毒免疫应答反应。本文将分别介绍丝/苏氨酸蛋白磷酸酶、酪氨酸蛋白磷酸酶和脂类磷酸酶在抗病毒天然免疫应答中的调控作用。Protein phosphatases play critical roles in regulating cell division,cell apoptosis,and cell cycle in eukaryotic cells,participating in numerous signal transduction processes and exerting a large amount of significant biological functions.A variety of protein phosphatases are identified to maintian the phosphorylation level of key proteins with a moderate level in the antiviral innate immune response to virus infection.In this paper,we reviewed the roles of serine/threonine protein phosphatases,tyrosine protein phosphatases,and lipid phosphatases in regulating antiviral innate immune responses.

关 键 词：蛋白磷酸酶 Ⅰ型干扰素 抗病毒反应 天然免疫 

分 类 号：R392.12[医药卫生—免疫学]