胆汁酸与糖脂代谢疾病  

Bile acid in glucolipid metabolic diseases:an update

作　　者：何逸飞[1] 王奇金[1] 

机构地区：[1]第二军医大学长海医院内分泌科,上海200433

出　　处：《第二军医大学学报》2017年第6期780-784,共5页Academic Journal of Second Military Medical University

基　　金：长海医院探索项目(CH125541900)~~

摘　　要：胆汁酸(bile acid,BA)作为胆汁的成分之一,参与脂肪消化吸收和胆固醇代谢。近年研究发现,胆汁酸还是一种信号分子,不仅可以与法尼酯衍生物X受体(farnesoid X receptor,FXR)、G蛋白偶联胆汁酸受体(G protein coupled bile acid receptor 5,TGR5)等结合调节自身代谢,还在糖尿病、肥胖、非酒精性脂肪肝病及其他代谢性疾病中发挥重要作用,因此,阐明其作用机制将为诊治代谢性疾病提供理论依据。本文就胆汁酸在糖脂代谢疾病中的研究进展作一综述。Bile acids,as one of the constituents of bile,can promote the digestion and absorption of fat and cholesterol metabolism.Studies find that bile acid is a signal molecule that not only combines with nuclear hormone receptors such as farnesoid X receptor,and G protein coupled bile acid receptor 5,to regulate their own metabolism,but also plays an important role in diabetes,obesity,non-alcoholic fatty liver disease and other metabolic diseases.The research on its mechanism will provide a solid theoretical basis for the diagnosis and treatment of metabolic diseases.In this review,we summarized the research progress of bile acids in glucolipid metabolic diseases.

关 键 词：胆汁酸类和盐类 2型糖尿病 减重手术 非酒精性脂肪肝 法尼酯衍生物X受体 G蛋白偶联的胆汁酸受体 

分 类 号：R58[医药卫生—内分泌]