酰胺基水杨醛Schiff碱的合成及抗菌活性研究  

Synthesis of Schiff Base Containing Salicylaldehyde and Amide and Its Antibacterial Activity

作　　者：徐文广 叶亚娟 姜凌 李顺清 张芳芳 蔡丽华 

机构地区：[1]武汉工商学院环境与生物工程学院实验中心,湖北武汉430065

出　　处：《绿色科技》2017年第12期20-21,25,共3页Journal of Green Science and Technology

基　　金：湖北省教育厅科研计划基金资助项目(编号:B2016338);湖北省大学生创新创业训练计划资助项目标(编号:201613242014)

摘　　要：以氨基酸、水杨醛为主要原料,合成了五种Schiff碱,通过元素分析、紫外吸收、质谱等测试手段进行了结构鉴定,并采用琼脂扩散法分别测定了各Schiff碱对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌的抑菌活性,结果表明:新合成的五种Schiff碱均具有抗菌作用,抗菌活性分别为色氨酸Schiff碱对大肠杆菌的作用最强,丝氨酸Schiff碱对金黄色葡萄球菌的抑菌作用最强,谷氨酸Schiff碱对枯草芽孢杆菌的抑菌作用最强。The five Schiff bases were synthesized by using amino acid and salicylaldehyde as main materials. The structures were identified by IR, Uv and MR. The inhibitory activities of compounds on Escherichia coli, Staphylo-coccus aureusandBacillus subtiliswere primarily studied through the Agar Diffusion Assay method. The results showedthat the five Schiff bases had antibacterial activity. Respectively glutamic acid Schiff bases has the strongest on escherichia coli, serine Schiff base had the strongest bacteriostasis to staphylococcus aureus and alanine Schiff base had the strongest bacteriostass on bacillus subtilis.

关 键 词：水杨醛 氨基酸 SCHIFF碱 合成 抗菌活性 

分 类 号：O627.41[理学—有机化学]