老年阻塞性睡眠呼吸暂停综合征与体质量指数、血压、血脂及血糖的相关性  

Correlation between OSAS and BMI,blood pressure,blood lipid and blood glucose in elderly patients

作　　者：谢灿果[1,2] 王琦[2] 尤华[3] 

机构地区：[1]湖北医药学院附属随州医院呼吸内科,湖北随州441300 [2]湖北省随州市中心医院呼吸内科,湖北随州441300 [3]湖北省随州市中心医院麻醉科,湖北随州441300

出　　处：《实用临床医药杂志》2017年第11期42-44,共3页Journal of Clinical Medicine in Practice

基　　金：湖北省卫计委面上项目(JX6B145)

摘　　要：目的探讨老年阻塞性睡眠呼吸暂停综合征与患者的体质量指数、血压、血脂及血糖的相关性。方法将118例OSAS患者作为试验组,98例健康人作为对照组,比较2组患者的体质量指数、血压、血脂、血糖以及甘油三酯(TG)、血清胆固醇(TC)和C反应蛋白(CRP)等指标。结果试验组患者的MAP和BMI以及收缩压均显著高于对照组(P<0.05),而2组患者的舒张压、臀围及腰围则无显著差异(P>0.05)。2组患者的血清TC、HDL-C、LDL-C等均无显著差异(P>0.05),试验组患者的血清TG和血糖、Fig、CRP等水平则显著高于对照组(P<0.05),而CGRP则水平则显著低于对照组(P<0.05)。试验组患者的Sa O2<90%时间百分数、Sa O2<90%时间、低氧指数、低氧频数、呼吸紊乱次数等均显著高于对照组(P<0.05),而最低Sa O2则显著低于对照组(P<0.05)。试验组患者心血管疾病的发病率为80.5%,显著高于对照组的27.6%(P<0.01)。经Logistic回归分析显示,患者的低氧指数和CGRP水平、TG水平以及颈围等均与OSAS呈正相关关系(P<0.05)。结论老年OSAS和心血管疾病危险因素存在极为密切的关系。Objective To investigate the correlation between obstructive sleep apnea syn- drome （OSAS） and body mass index, blood pressure, blood lipid and blood glucose in elderly pa- tients. Methods A total of 118 elderly male patients with OSAS were selected as experimental group, and 98 healthy people were selected as control group. The body mass index, blood pressure, blood lip- id, blood glucose and triglycerides （TG）, serum cholesterol （TC）, tumor necrosis and c-reactive pro- tein （CRP）, and other indicators were compared. Results The MAP, BMI and systolic blood pres- sure in experimental group were significantly higher than those in control group （P 〈 0.05 ）, while there were no significant differences in diastolic blood pressure and hip and waist circumference （P 〉 0.05 ）. There were no significant differences between the two groups in serum TC, HDL-C and LDL-C （ P 〉 0.05 ）, the serum TG and blood glucose, Fig and CRP levels in experimental group were signifi- cantly higher than those in control group （P 〈 0.05 ）, and the CGRP level was significantly lower than the control group （P 〈0.05 ）. In the experimental group, SaO2 〈 90%, SaO2 〈 90% the percentage of the time, oxygen index, hypoxia frequency, respiratory disturbance frequency were significantly higher than the control group （ P 〈 0.05 ）, while the lowest SaO2 was significantly lower than the control group （P 〈0.05）. The incidence rate of cardiovascular disease in the experimental group was 80.5%, which was significantly higher than 27.6% in the control group （P 〈0.01 ）. Logistic regression analysis showed that there was a positive correlation between OSAS index and CGRP level , TG level and neck circumference （P 〈 0.05 ）. Conclusion There is a close relationship between OSAS and cardiovascular disease risk factors in elderly patients.

关 键 词：阻塞性睡眠呼吸暂停综合征 血压 血脂 心血管疾病 相关性 

分 类 号：R441.8[医药卫生—诊断学]