冠状动脉慢血流患者检测外周血T淋巴细胞及其亚群与C-反应蛋白的意义  

The significance of testing peripheral blood T lymphocytes and its subsets and C-reactive protein in coronary slow flow patients

作　　者：徐香山[1] 金元哲[1] 

机构地区：[1]中国医科大学附属第四医院心血管内科,沈阳110032

出　　处：《免疫学杂志》2017年第7期602-606,共5页Immunological Journal

摘　　要：目的联合检测C反应蛋白和T淋巴细胞及其亚群2个指标进一步评估其在慢血流中的价值。方法选择2010年1月至2015年12月于中国医科大学附属第四医院心血管内科行冠状动脉造影诊断为CSF的住院患者30例,另选同期CAG正常者30例作为对照组。所有患者检测血常规、血脂、肝肾功能、血糖、T淋巴细胞及其亚群、C反应蛋白等。结果慢血流组患者的外周血T淋巴细胞亚群的CD3^+T淋巴细胞、CD4^+T淋巴细胞以及CD4^+/CD8^+的比率明显降低,慢血流组的CRP水平明显高于对照组。Logistic回归分析提示吸烟、CRP、CD4/CD8的比值是慢血流的独立危险因素。结论冠状动脉慢血流的患者免疫功能受到损伤,C反应蛋白与T淋巴细胞亚群之间存在着某种联系,表明炎症反应在慢血流形成中的作用。The study aims to detect the changes of C reactive protein and T lymphocyte subsets, and evaluate their clinical values in coronary slow flow. Total of 30 patients were enrolled from cardiovascular department in the Fourth Affiliated Hospital of China Medical University from January 2010 to December 2015, who were diagnosed coronary slow flow after coronary angiography, meanwhile 30 patients with normal coronary angiography were selected as the control group. Blood routine examination, liver and kidney function, blood lipid, blood glucose, uric acid, T lymphocyte subsets and C reactive protein（CRP） were recorded. Data showed that CD3^＋T lymphocytes, CD4^＋T lymphocytes and CD4^＋/CD8^＋ratio in peripheral blood of slow blood flow group decreased significantly, while the level of CRP was significantly higher, as compared with the control group. Logistic regression analysis indicated that smoking, CRP and the ratio of CD4/CD8 are independent risk factors for slow flow. Taken together, immune function in coronary slow flow patients is damaged; there is a certain relationship between the CRP and T lymphocyte subsets, which indicates that inflammation plays an important role in the formation of slow blood flow.

关 键 词：C反应蛋白 T淋巴细胞亚群 慢血流 

分 类 号：R543.3[医药卫生—心血管疾病]