基质金属蛋白酶9在早孕绒毛组织与早期自然流产绒毛组织中的表达变化  

The expression differences of MMP-9 in villi between patients with normal early pregnancy and early spontaneous abortion

作　　者：杨文慧[1] 武云飞[2] YANG Wenhui WU Yunfei(Department of Obstetrics and Gynecology of Baotou Central Hospital, Baotou 014040, China Anesthesia Department of Baotou Central Hospital)

机构地区：[1]包头市中心医院妇产科,内蒙古包头014040 [2]包头市中心医院麻醉科

出　　处：《包头医学院学报》2017年第6期75-77,共3页Journal of Baotou Medical College

摘　　要：目的:观察早期自然流产患者与正常早期妊娠妇女的绒毛中基质金属蛋白酶9(matrix metalloproteinases 9,MMP-9)的表达情况,探讨其在绒毛发育过程中可能发挥的作用。方法:选择2013年12月至20014年12月因早期自然流产行清宫术的患者30例、因计划生育因素自愿行人工流产的早期妊娠妇女30例为研究对象。收集两组患者的部分绒毛组织,采用免疫组织化学法进行MMP-9蛋白在两组绒毛组织中的定位及半定量分析。结果:MMP-9在早期自然流产组及正常早期妊娠组的绒毛小叶的合体滋养细胞及细胞滋养细胞中均有表达,MMP-9在正常妊娠妇女的绒毛中表达为强阳性,但在早期自然流产患者的绒毛中的表达为弱阳性。半定量分析显示MMP-9在早期自然流产组的绒毛组织中的阳性表达率为36.7%,而正常早期妊娠组为73.3%,组间比较,差异有统计学意义(P<0.05)。结论:MMP-9蛋白可能参与绒毛的发育。Objective： To study the expression differences of matrix metalloproteinases 9 （ MMP - 9 ） in villi between patients with early spontaneous abortion and normal early pregnancy, and explore its function in the development of villi. Methods：30 early spontaneous abortion patients and 30 normal early pregnancy women volunteering for artificial abortion because of family planning from December 2013 to December 2014 were selected as research subjects and a part of their villous tis- sues were collected. Immunohistochemical method was adopted to analyze the distribution and make semi - quantitative analysis of MMP - 9 in the villus of the two groups. Results： MMP - 9 was expressed in syncytiotrophoblast and cytotrophoblast of villous leaflets in both early spontaneous abortion and normal early pregnancy, in which the expression of MMP - 9 in normal early pregnancy was powerfully positive and in early spontaneous abortion was weakly positive. Semi - quantitative analy- sis showed there was statistical significance between the MMP -9 positive expression rate in early spontaneous abortion （36.7 % ） and that in normal early pregnancy （73.3 % ） （ P 〈 0.05 ）. Conclusion： The villous expression of MMP - 9 protein in the two groups shows that it may participate in the development of villi.

关 键 词：基质金属蛋白酶9 早期自然流产 

分 类 号：R714.21[医药卫生—妇产科学]