稳心颗粒联合美托洛尔治疗老年人冠心病心律失常的疗效及其安全性分析  

Efficacy and safety of Wenxin granule combined with metoprolol in the treatment of arrhythmia in elderly patients with coronary heart disease

作　　者：王国菊[1] 陈运海[1] 毛丽娟[1] WANG Guo-ju CHEN Yun-hai MAO Li-juan(Department of Internal Medicine, Qingyuan Hospital of Traditional Chinese Medicine, Lishui 323800, Chin)

机构地区：[1]庆元县中医院内科

出　　处：《中国生化药物杂志》2017年第6期325-327,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨稳心颗粒联合美托洛尔治疗老年人冠心病心律失常的疗效以及安全性.方法 选取2014年4月-2016年5月在庆元县中医院内科接受治疗的老年人冠心病心律失常患者84例,采用随机数表法将患者分为观察组和对照组,每组42例,观察组给予稳心颗粒联合美托洛尔治疗,对照组给予美托洛尔治疗,比较2组患者治疗前后收缩期情况变化、治疗前后缺血情况、血流动力学变化情况以及血浆黏度,比较2组治疗后临床效果.结果 治疗后,2组患者的房性期前收缩、室性期前收缩以及交界性期前收缩都有所下降,观察组低于对照组,2组比较差异有统计学意义（P〈0.05）;治疗后,2组患者缺血发生次数都有所降低,观察组（5.45±1.12）次低于对照组（8.12±2.70）次,2组比较差异有统计学意义（P〈0.05）;治疗后,2组患者的缺血总时间都有所减短,观察组（16.45±3.87）min短于对照组（22.45±4.89）min,2组比较差异有统计学意义（P〈0.05）;观察组总有效率92.85%高于对照组69.20%,差异有统计学意义（P〈0.05）.结论 给予老年人冠心病心律失常患者稳心颗粒联合美托洛尔治疗,能够有效改善患者的临床症状,效果显著.Objective To investigate the efficacy and safety of Wenxin Granule Combined with metoprolol in the treatment of arrhythmia in elderly patients with coronary heart disease.Methods84 cases of elderly patients with coronary heart disease arrhythmia treated in our hospital from April 2014 to May 2016, were randomly divided into observation group and control group, 42 cases in each group.The observation group was given the Wenxin Granule Combined with metoprolol treatment, the control group were treated with metoprolol,The changes of systolic status, the ischemic condition, hemodynamic changes and plasma viscosity were compared before and after treatment between the two groups, and the clinical effect after treatment were compared.ResultsAfter treatment, two groups of patients with atrial premature contraction, ventricular premature contractions and junctional premature contractions were decreased, the observation group was lower than the control group, the difference between the two groups was statistically significant （P〈0.05）;After treatment, two groups of patients with ischemic frequency were reduced, the observation group （5.45±1.12）times was lower than the control group （8.12±2.70）times, the difference between the two groups was statistically significant （P〈0.05）;After treatment, the two groups of patients with total ischemic time is shortened, the observation group （16.45±3.87）min shorter than the control group （22.45±4.89）min, the difference between the two groups was statistically significant （P〈0.05）;The total effective rate of the observation group was 92.85% higher than the control group （69.20%）, the difference was statistically significant（P〈0.05）.ConclusionElderly patients with coronary heart disease arrhythmia patients with Wenxin granule combined with metoprolol treatment, can effectively improve the clinical symptoms of patients with significant effect.

关 键 词：稳心颗粒 美托洛尔 冠心病心律失常 疗效 

分 类 号：R541.4[医药卫生—心血管疾病]