快室率房颤伴心力衰竭采用胺碘酮联合琥珀美托洛尔缓释片治疗对其心功能的影响  

Effects of amiodarone combined with succinylmetroprolol sustained-release tablets on cardiac function in patients with atrial fibrillation and congestive heart failure

作　　者：荣仔萍[1] 董十月[2] RONG Zai-ping DONG Shi-yue(Department of Comprehensive Surgery, People＇s Hospital of Anji County, Zhejiang, Huzhou 313300, China Department of Cardiology, People＇s Hospital of Anji County, Huzhou 313300, China)

机构地区：[1]浙江省安吉县人民医院综合科,浙江湖州313300 [2]安吉县人民医院心内科,浙江湖州313300

出　　处：《中国生化药物杂志》2017年第6期344-346,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨快室率房颤伴心力衰竭患者采用胺碘酮联合琥珀美托洛尔缓释片治疗临床疗效,并观察其对患者心功能、心室率的影响.方法 截选医院2013年6月-2016年6月80例快室率房颤伴心力衰竭患者纳入此次研究对象,按照随机数字表法将其分组为对照组与治疗组,各40例.于治疗前、治疗6个月后分别评价2组心室率（活动后心室率、静息心室率）、心功能变化（射血分数-EF、心搏量-SV、心输出量-CO及左心室舒张早期/晚期速度峰值比值-VA/VE）,统计2组临床治疗效果及治疗期间所发生不良反应.结果 2组患者治疗6个月后运动后心室率、静息心室率均明显低于治疗前,而治疗组治疗6个月后运动后心室率、静息心室率明显低于对照组（P〈0.05）.2组患者治疗6个月后VA/VE值明显低于治疗前,EF、SV、CO明显高于治疗前,而治疗组治疗6个月后VA/VE值明显低于对照组,EF、SV、CO明显高于对照组（P〈0.05）.治疗组治疗总有效率92.5%,明显高于对照组72.5%（χ2=7.77,P=0.02）.治疗期间未见明显不良反应.结论 快室率房颤伴心力衰竭患者采用胺碘酮联合琥珀美托洛尔缓释片可有利于患者心室率及心功能的改善,且效果显著、安全,因此可推荐为临床患者治疗首选药物.Objective To investigate the clinical efficacy of amiodarone combined with succinylmetroprolol sustained-release tablets in patients with atrial fibrillation and congestive heart failure （CHF） complicated with atrial fibrillation （AF）, and to observe the effect of amiodarone on heart function and ventricular rate.MethodsIn people＆#39;s hospital of Anji county from June 2013 to June 2016 a total of 80 patients with atrial fibrillation and heart failure were enrolled in this study.The patients were randomly divided into control group and treatment group, 40 cases.（Ventricular rate, resting ventricular rate）, cardiac function （ejection fraction-EF, stroke volume-SV, cardiac output-CO and left ventricular function） were measured before treatment and 6 months after treatment Ventricular end-diastolic early/late peak velocity ratio-VA/VE）.The clinical efficacy and side effects during the treatment were statistically analyzed.ResultsThe ventricular rate and resting ventricular rate after exercise were significantly lower than those before treatment, but the ventricular rate and resting ventricular rate were significantly lower in the treatment group than those in the control group after 6 months of treatment （P〈0.05）.The VA/VE was significantly lower than that of the control group at 6 months after treatment, and the values of EF, SV and CO were significantly higher than those of the control group at 6 months after the treatment, SV, CO were significantly higher than the control group（P〈0.05）.Treatment group, the total effective rate was 92.5%, significantly higher than the control group 72.5%（χ2=7.77, P=0.02）.No significant adverse reactions during treatment.ConclusionRapid ventricular rate of atrial fibrillation with congestive heart failure were treated with amiodarone combined with metoprolol succinate sustained release tablets can conducive to the ventricular rate and heart function of patients, and the effect is remarkable, safe, so it can be recommended as the drug of choice f

关 键 词：快室率房颤伴心力衰竭 盐酸胺碘酮注射液 琥珀美托洛尔缓释片 心室率 心功能 

分 类 号：R541.7[医药卫生—心血管疾病]