小儿病毒性脑炎患者预后影响因素分析  

Analysis on prognostic influencing factors of children with viral encephalitis

作　　者：梁国安[1] 姚桂飞[1] LIANG Guo-an YAO Gui-fei(Taizhou Hospital of Zhejiang Province, Linhai , Zhejiang 317000, China)

机构地区：[1]浙江省台州医院,浙江临海317000

出　　处：《中国公共卫生管理》2017年第3期405-407,共3页Chinese Journal of Public Health Management

摘　　要：目的分析小儿病毒性脑炎(VE)预后的影响因素,为小儿VE诊治方案和预后评估提供参考。方法选择2015年10月-2016年10月浙江省台州医院收治的88例重症VE患儿作为研究对象,根据预后情况分为预后良好组50例和预后不良组38例,采用Logistic回归分析影响重症VE患儿预后的影响因素。结果预后良好组惊厥时间、惊厥发生率、发热时间、意识障碍时间、头颅磁共振成像(MRI)异常发生率和脑电图(EEG)异常发生率均低于预后不良组;格拉斯哥预后评分(GOS)高于预后不良组(P<0.05);两组患儿年龄、性别、住院时间、脑脊液(CSF)蛋白量、CSF白细胞计数以及发热、意识障碍、低钾血症、低钠血症发生率比较,差异无统计学意义(P>0.05)。Logistic回归分析显示,惊厥时间、发热时间、意识障碍时间、GOS评分、头颅MRI异常和EEG异常是影响重症VE患儿预后的危险因素(P<0.05)。结论惊厥时间、发热时间、意识障碍时间、头颅MRI异常和EEG异常是影响重症VE患儿预后的重要危险因素,应给予足够的重视,以改善VE患儿的预后。Objective To analyze the prognostic influencing factors of children with viral encephalitis （VE） and provide reference for the diagnosis, treatment and prognosis of children with VE. Methods 88 cases of severe VE were selected in our hospital from October 2015 to October 2016 as the research object,who were divided into good prognosis group （n = 50） and poor prognosis group （ n = 38 ） according to the prognosis. Logistic regression analysis was used to analyze prognostic influencing factors of children with severe VE. Results Convulsion time, seizure incidence, duration of fever, disturbance of consciousness time, Glasgow Outcome Scale, abnormal brain MRI and abnormal EEG in good prognosis group were lower than those of the poor prognosis group （ P 〈 0.05 ） , and age, gender, duration of hospitalization, cerebrospinal fluid （CSF） protein, CSF and white blood cell counts, fever, disturbance of consciousness, hypokalemia, hyponatremia incidence in two groups were no significant difference （P 〉 0.05 ）. Logistic regression analysis showed that convulsion time, fever time, conscious disturbance time, GOS, abnormal cranial MRI and abnormal EEG were the important risk factors for the prognosis of children with severe VE. Conclusion Convulsion time, duration of fever, disturbance of consciousness, time consciousness disorder, abnormal brain MRI and abnormal EEG are important risk factors for the prognosis of children with severe VE, and patients should be given enough attention, in order to ensure the quality of prognosis of VE in children.

关 键 词：小儿 病毒性脑炎 预后 影响因素 

分 类 号：R373.31[医药卫生—病原生物学]