2008-2011年新疆维吾尔自治区5岁以下腹泻儿童人杯状病毒感染分析  

Analysis of human calicivirus infection in children under 5 years of age in the Xinjiang Uygur autonomous region from 2008 to 2011

作　　者：沙比热木·托合塔木[1] 赵俊[1] 郜振国[1] 刘红斌[1] 马合木提[1] Shabiremu.tuohetamu Zhao Jun Gao Zhenguo Liu Hongbin Mahe Muti(Department of infectious diseases prevention and control, Xinjiang Uygur Autonomous Region Center for Disease Prevention and Control, Urumqi 830002, Chin)

机构地区：[1]新疆维吾尔自治区疾病预防控制中心传染病防制科,乌鲁木齐830002

出　　处：《国际病毒学杂志》2017年第3期171-173,共3页International Journal of Virology

摘　　要：目的了解新疆5岁以下腹泻儿童人杯状病毒感染的流行特征。方法收集2008-2011年新疆782份5岁以下腹泻儿童粪便标本，利用RT-PCR方法进行杯状病毒检测。结果杯状病毒阳性率为12．7％，其中男性儿童中为12．4％，女性为13．1％；2008-2011四年阳性率分别为11．3％、16．0％、11．9％和11．5％；城镇地区为12．1％，农村地区为16．0％；不同年度、地区和性别之间差异均无统计学意义。5岁以下儿童中，6月以下、6-12月、1-2岁、〉2岁年龄组阳性率分别为10．2％、15．6％、13．8％、3．0％，差异有统计学意义（x2=8．149，P〈0．05）。结论杯状病毒感染是引起新疆5岁以下儿童腹泻的主要病原之一，2008-2011年间的阳性率为12．7％，2岁以下儿童感染风险最高。Objective To investigate the epidemiological characteristics of human calicivirus infection in children less than 5 years old in Xinjiang, China. Methods A total of 782 stool specimens were collected from children younger than 5 years old with diarrhea between 2008 and 2011. Human caliciviruses were detected by RT-PCR. Results Human caliciviruses were detected in 12.7% （99/782） of the patients. The positive rates were 12.4% （58/468） in male and 13.1% （41/314） in female, respectively. The annual positive rates were 11.3% （13/115） in 2008, 16.0% （28/175） in 2009, 11.9% （45/379） in 2010, and 11.5% （13/113） in 2011, respectively. In urban area the positive rate was 12.1% while in rural area the rate was 16.0%. The results showed no statistically significant differences between years, regions and genders. In different age goups of less than 6 months, 6-12 months, 1-2 years and 〉2 years old, the positive rates were 10.2% （32/313）, 15.6% （49/313）, 13.8% （17/123）, and 3.0% （1/33） with statistically significant difference （x2=8.149, P〈0.05）. Conclusions Human Calicivirus was an important pathogen causing diarrhea in children under 5 years old in Xinjiang, with a positive rate of 12.7% during 2008-2011. Children under 2 years of age had the highest risk of infection.

关 键 词：人杯状病毒 5岁以下儿童 腹泻 流行病学 

分 类 号：R725.1[医药卫生—儿科]