CRP、D-二聚体和BNP浓度与急性肺栓塞患者不良事件相关性研究  

Study on the correlation between serum CRP,DD,BNP and adverse events in patients with acute pulmonary embolism

作　　者：冷文文[1] 章超[1] 赵璇[1] LENG Wen-wen ZHANG Chao ZHAO Xuan(Department of Respiratory Medicine,the First People＇s Hospital of Jiujiang in Jiangxi province,Jiujiang 332000,Chin)

机构地区：[1]江西省九江市第一人民医院呼吸内科,江西九江332000

出　　处：《中国当代医药》2017年第17期30-32,共3页China Modern Medicine

基　　金：江西省九江市科技支撑计划项目(2016204)

摘　　要：目的探究C反应蛋白(CRP)、D-二聚体(DD)、脑钠肽(BNP)水平在急性肺栓塞短期治疗预后评价中的临床价值。方法选择2014年10月~2016年10月我院呼吸内科确诊为急性肺栓塞的患者30例,根据未治疗前的检测结果将患者分为高浓度组(同时满足DD>5000 ns/ml、CRP>10 mg/L、BNP>500 ng/L)和低浓度组(同时满足DD<4999 ns/ml、CRP<10 mg/L、BNP<500ng/L),每组15例,记录并比较两组患者在治疗期间和出院后3个月内不良反应发生情况,利用Logistic线性回归分析血液CRP、DD、BNP浓度与不良事件相关性大小。结果高浓度组患者心源性休克、死亡人数以及3个月内死亡人数所占比例,均明显高于低浓度组,差异有统计学意义(P<0.05);死亡患者治疗前的血液CRP、BNP平均水平明显高于非死亡患者,差异有统计学意义(P<0.05),而两组DD水平差异无统计学差异(P>0.05),Logistic线性回归分析显示,患者治疗前的血液CRP、BNP、DD水平均与临床不良事件有较高相关性。结论治疗前CRP、DD、BNP浓度测定对急性肺栓塞短期治疗的预后评价有较高临床价值,值得推广应用。Objective To investigate the clinical value of C reactive protein（CRP）,D-dimer（DD）and brain natriuretic peptide（BNP） in the short-term prognosis of acute pulmonary embolism（PE）.Methods 30 cases treated in our respiration medicine from October 2014 to October 2016 of acute pulmonary embolism patients were divided into high concentration group（DD〉5000 ns/ml,CRP〉10 mg/L,BNP〉500 ng/L） and low concentration group（DD〉4999 ns/ml,CRP〉10mg/L,BNP 〈500 ng/L）,15 cases in each group.The adverse eventin the two groups was recorded and analyzed during treatment and after 3 months.Logistic linear regression analysis was used to analyze the correlation between the concentration of CRP, DD,BNP and adverse event.Results The number of deaths within 3 months in the high concentration group was significantly higher than that of the low concentration group,the difference was statistically significant（P〈0.05）; The concentration of CRP,BNP in dead patients was significantly higher than those of the survived patients,the difference was statistically significant（P〈0.05）.While the concentration of DD in two groups had no statistically difference（P〉0.05）.Logistic linear regression analysis showed that the concentration blood CRP,BNP,DD level before treated had a high correlation with death.Conclusion The concentration of CRP, DD and BNP before treated has a high clinical value in the short-term prognosis of acute pulmonary embolism,and it is worth promoting.

关 键 词：急性肺栓塞 C反应蛋白 D-二聚体 脑钠肽 预后评价 

分 类 号：R563.5[医药卫生—呼吸系统]