鼓室内注入类固醇激素治疗伴糖尿病的突发性聋Meta分析  

Intratympanic steroid injection treatment of sudden hearing loss with diabetes:a Meta-analysis

作　　者：刘文[1] 黄晓悫[1] 

机构地区：[1]重钢总医院耳鼻咽喉科,重庆400000

出　　处：《中国耳鼻咽喉头颈外科》2017年第6期291-295,共5页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的评价鼓室内注射类固醇激素治疗伴糖尿病的突发性聋疗效及安全性。方法检索Pubmed、Medline、CNKI、CBM、维普、万方数据库,收集符合纳入标准的文献并提取数据,利用RevMan5.3进行Meta分析。结果共纳入9篇文献,总耳数587耳,其中294耳接受鼓室内类固醇激素治疗,为试验组;另293耳为对照组,包括全身使用类固醇激素217耳及非激素全身治疗76耳。Meta分析结果表明试验组较对照组的临床效果显著(Z=3.65,P<0.05;Z=3.70,P<0.05)。试验组较对照组对血糖的影响更小(χ~2=7.471,P<0.05)。鼓室内注药其他并发症主要有可自行愈合的鼓膜穿孔、短暂眩晕等。结论鼓室内注射类固醇激素治疗伴糖尿病的突发性聋效果显著,且对血糖影响较小、局部并发症轻,在临床实践中可优先考虑。OBJECTIVE To evaluate the efficacyand safety of intratympanic injection of steroids in the treatment of sudden hearing loss with diabetes. METHODS PubMed, Medline, CNKI, CBM, VIP, and Wanfang databases were searched by electronic retrieval to collect documents meeting the inclusion criteria and extract data.Meta-analysis was performed using RevMan 5.3. RESULTS There were 9 articles included in the literature search,a total number of 587 ears, of which 294 ears accepted intratympanic injection of steroids as the experimental group. Another 293 ears was control group,of which 217 ears accepted systemic steroids and 76 ears accepted non-hormone therapy.Meta analysis results showed that the clinical effect of experimental group was more remarkable than that of the control group （Z=3.65, P〈0.05; Z=3.70, P〈0.05）. The influence on blood sugar in experimental group was smaller than that of the control group （χ2=7.471, P〈 0.05）. Other complications of intratympanic steroid injection were self-healing after tympanic membrane perforation, transient dizziness and so on. CONCLUSION There was a significant effect on patients with sudden hearing loss and diabetes through intratympanic steroid injection. It has little effect on blood glucose and slight complications, which is a priority in clinical practice.

关 键 词：听觉丧失 突发性 临床方案 糖皮质激素类 中耳 META分析 

分 类 号：R587.1[医药卫生—内分泌] R764.437[医药卫生—内科学]