珍芪降糖胶囊联合西格列汀片治疗2型糖尿病  

Zhenqi Jiangtang capsule and sitagliptin phosphate tablets in the treatment of type 2 diabetes mellitus

作　　者：林源[1] 高海燕[1] 郭亚菊[1] 宋书贤[1] 张琼[1] LIN Yuan GAO Haiyan GUO Yaju SONG Shuxian ZHANG Qiong(The Second Affiliated Hospital of Xi＇ an Medical College, Xi＇ an 710038, China)

机构地区：[1]西安医学院第二附属医院,西安710038

出　　处：《吉林中医药》2017年第6期560-563,共4页Jilin Journal of Chinese Medicine

基　　金：陕西省科学技术研究发展计划项目(2014k11-03-04-05)

摘　　要：目的观察珍芪降糖胶囊联合西格列汀片治疗2型糖尿病的临床疗效。方法选取我院收治的94例2型糖尿病患者作为研究对象,随机分为观察组与对照组。对照组给予西格列汀片治疗,1次/d,1片/次;观察组在对照组的基础上给予珍芪降糖胶囊(3次/d,4粒/次;治疗后,评价2组治疗效果。治疗前后,分别检测2组患者三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)等血脂指标含量;检测2组患者空腹血糖值(FBG)、餐后2 h血糖(2 h PG)、胰高血糖素样肽1(GLP-1)、空腹胰岛素(FINS)及糖化血红蛋白(Hb Alc)等血糖指标含量;检测2组患者总抗氧化能力(T-Aoc)、谷胱甘肽过氧化物酶(GSH-PX)及超氧化物歧化酶(SOD)等氧化应激指标含量。观察治疗期间患者的不良反应发生情况。结果治疗后,观察组总有效率为91.2%,明显高于对照组的78.7%(P<0.05)。治疗后,观察组TC、TG、LDL-C、FBG、2 h PG及Hb Alc含量分别为(5.72±1.14)mmol/L、(2.17±0.46)mmol/L、(2.62±0.81)mmol/L、(6.12±0.84)mmol/L、(6.72±0.49)mmol/L,均明显低于对照组(P<0.05),而SOD、T-Aoc、GSH-PX、HDL-C及GLP-1则明显高于对照组(P<0.05)。治疗期间,所有患者均未出现严重不良反应。结论珍芪降糖胶囊联合西格列汀片治疗2型糖尿病可有效改善患者血脂指标及血糖指标。Objective To observe the clinical effect ofZhenqi Jiangtang capsule and sitagliptin phosphate tablets in patients with type 2 diabetes.Methods 94 patients of type 2 diabetes mellitus in our hospital were selected as research object and randomly divided into observation group and control group. The control group was given sitagliptin phosphate tablets, 1/d, 1/ times; Observation group was givenZhenqi Jiangtang capsule on the basis of the control group, 3/d, 4/times. After the treatment, to evaluate the clinical effect of the two groups. Before and after treatment, triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） and blood lipid content were respectively detected on the two groups; Fasting blood glucose （FBG）, 2 h postprandial blood glucose （2 hPG）, glucagon like peptide 1 （GLP-1）, fasting insulin （FINS） and glycosylated hemoglobin （HbAlc） and other indexes of blood glucose content were detected on two groups; Total antioxidant ability （T-AOC）, glutathione peroxidase （GSH-Px） and superoxide dismutase （SOD） and other indicators of oxidative stress were detected on the two groups. The adverse reactions were observed in the patients during the treatment.ResultsAfter treatment, the total effective rate of observation group was 91.2%, significantly higher than the control group 78.7% （P〈0.05）. After treatment, TC, TG, LDL-C, FBG, 2hPG and HbAlc were （5.72±1.14） mmol/l, （2.17±0.46） mmol/l, （2.62±0.81） mmol/l, （6.12±0.84） mmol/l, （6.72±0.49） mmol/l in the observation group were significantly lower than the control group （P〈0.05）, while SOD, T-AOC, GSH-Px, HDL-C and GLP-1 were significantly higher than that of the control group （P〈0.05）. During the treatment, there were no serious adverse reaction in all patients.ConclusionZhenqi Jiangtang capsule and sitagliptin phosphate tablets in patients with type 2 diabetes can effectively improve blood lipid

关 键 词：珍芪降糖胶囊 西格列汀片 2型糖尿病 

分 类 号：R287[医药卫生—中药学]