大剂量阿托伐他汀对不稳定性心绞痛患者冠脉狭窄程度hs-CRP的影响  

High Dose Atorvastatin on Coronary Artery Stenosis and hs-CRP in Patients with Unstable Angina Pectoris

作　　者：卢清玉[1] 常宇锋[1] 刘庚[1] LU Qingyu CHANG Yufeng LIU Geng(Haidian Hospital of Beijing/Haidian Branch of the Third Hospital of Peking University, Beijing Haidian District 100080, China)

机构地区：[1]北京市海淀医院/北京大学第三医院海淀院区,北京海淀区100080

出　　处：《河北医学》2017年第6期902-904,共3页Hebei Medicine

摘　　要：目的:探讨大剂量阿托伐他汀对不稳定性心绞痛(unstable angina,UA)患者冠脉狭窄程度、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)的影响。方法:以2013年7月至2015年7月我院UA患者145例为研究对象,按随机数字表法分为对照组和研究组。两组均给予阿司匹林、美托洛尔、硝酸异山梨酯片等常规药物进行治疗,同时对照组(70例)给予阿托伐他汀10mg/d,研究组(75例)给予阿托伐他汀40mg/d。分别于治疗前、治疗7d、治疗15d、治疗30d记录两组患者的超敏C反应蛋白(hs-CRP)及脂蛋白a水平,并采用Pearson相关分析对冠脉狭窄程度与hs-CRP关系进行统计分析。结果:治疗7d、15d后,研究组hs-CRP显著低于对照组(P<0.05);治疗15d、30d后,研究组血管栓塞率显著低于对照组(P<0.05)。且Pearson相关分析显示:hs-CRP与冠状动脉狭窄程度显著相关(r=0.264,P=0.032;r=0.425,P=0.014)。结论:早期较大剂量应用阿托伐他汀可显著降低UA患者的hsCRP及血管栓塞率,且hs-CRP与冠状动脉狭窄程度呈正相关。Objective：To explore the influence of high-dose atorvastatin on the degree of coronary artery stenosis, hs-CRP for unstable angina （UA） patients.Methods： 145 cases of UA patients admitted in our hospital from July 2013 to July 2015 were choosen as the research object, and those patients were randomly divided into two groups by the random number table method： the control group and study group.Both groups were given aspirin, metoprolol, and isosorbide dinitrate tablets as the conventional treatment.In the meantime, the control group （70 cases） was given Atorvastatin 10mg per day;while the study group （75 cases） was given atorvastatin 40mg per day.Before and after treatment of 7d, 15d, 30d treatment, high sensitivity C reactive protein in the patients of the two groups （hs-CRP） and a-lipoprotein level were recorded.And the pearson correlation analysis on the relationship between hs-CRP and the degree of coronary artery stenosis were analyzed.Results： The hs-CRP level of the study group were all significantly lower than that of the control group after 7-day and 15-day＇＇s treatment （P〈0.05）;the vascular embolization rate of the study group was significantly lower than that of the control group after 15-day and 30-day＇＇s treatment （P〈0.05）.And Pearson correlation analysis revealed that the serum hs-CRP were all significantly associated with the degree of coronary artery stenosis （r=0.264, P=0.032;r=0.425, P=0.014）.Conclusion：Early large-dose application of atorvastatin can significantly reduce the level of hs-CRP and vascular embolization rate for UA patients, and the level of hs-CRP are positively correlated with the degree of coronary artery stenosis.

关 键 词：阿托伐他汀 不稳定型心绞痛 超敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]