社区老年人血尿酸水平与颈股脉搏波速度的相关性研究  

Correlation between serum uric acid and carotid-femoral pulse wave velocity in community-dwelling elderly

作　　者：刘超[1] 郑桃林[1] 杜万红[1] 刘小阳[1] 贾巧[1] 胡登利[1] 张勇[1] 刘礼军[1] 易美玲[1] 万华平[1] LIU Chao ZHENG Tao-Lin DU Wan-Hong LIU Xiao-Yang JIA Qiao HU Deng-Li ZHANG Yong LIU Li-Jun YI Mei-Ling WAN Hua-Ping(Department of Geriatrics, Chinese PLA Hospital No. 163, the Second Affiliated Hospital of Hunan Normal University, Changsha 410003, China)

机构地区：[1]湖南师范大学第二附属医院解放军第163医院老年病科,长沙410003

出　　处：《中华老年多器官疾病杂志》2017年第6期406-409,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：湖南省卫生计生委科研基金项目(C2015-028)~~

摘　　要：目的探讨社区老年人血尿酸水平与颈股脉搏波速度(cf-PWV)的相关性。方法入选2012年3月至2016年6月期间在湖南师范大学第二附属医院解放军第163医院体检中心进行体检的湖南片区军队干休所离退休的老年人840例。依据cf-PWV值分为两组:cf-PWV<9 m/s组(n=520)和cf-PWV≥9 m/s组(n=320)。分析比较两组的临床资料和实验室检查指标。采用SPSS17.0统计软件进行统计学分析。结果两组患者的空腹血糖(FPG)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、C-反应蛋白(hs-CRP)、胰岛素抵抗指数(HOMA-IR)和血尿酸间差异均具有统计学意义(P<0.05)。剔除年龄、性别、BMI、HOMA-IR等干扰因素,cf-PWV与SBP(r=0.351,P=0.017)、hs-CRP(r=0.250,P=0.033)和血尿酸水平(r=0.647,P=0.000)均呈显著正相关。结论血尿酸是cf-PWV的独立危险因素,可间接反映动脉僵硬度的进展。Objective To investigate the correlation between serum uric acid and carotid-femoral pulse wave velocity （cf-PWV） in community-dwelling elderly.Methods A total of 840 retired old persons living in the cadre＇s sanatorium from Hunan region who took physical examination in our hospital from March 2012 to June 2016 were recruited in this study.According to the results of cf-PWV, they were divided into 〈9 m/s group （n=520） and ≥9 m/s group （n=320）.The clinical data and laboratory examination results were collected and compared between the 2 groups.SPSS17.0 software was used to perfom statistical analysis.Results Significant differences were seen in fasting plasma glucose （FPG）, triglycerides （TG）, low density lipoprotein cholesterol （LDL-C）, high sensitivity C-reactive protein （hs-CRP）, homestasis model assessment of insulin resistance （HOMA-IR） and serum uric acid between the 2 groups （P〈0.05）.After adjusting for age, gender, body mass index （BMI）, HOMA-IR and other interference factors, cf-PWV were positively correlated with systolic blood pressure （SBP, r=0.351, P=0.017）, hs-CRP （r=0.250, P=0.033） and serum uric acid （r=0.647, P=0.000）.Conclusion Serum uric acid is an independent risk factor for cf-PWV, and can indirectly reflect the progression of arterial stiffness.

关 键 词：颈股脉搏波速度 血尿酸 高敏C-反应蛋白 动脉僵硬度 

分 类 号：R592[医药卫生—老年医学] R543.5[医药卫生—内科学]