丹芪祛瘀止痛颗粒对气虚血瘀型胃癌前病变患者胃黏膜组织TRAF1、4-1BB、Bcl-xL表达的影响  

Effect of Danqi Ququ Zhitong Particles (丹芪祛瘀止痛颗粒) on Expressions of TRAF1,4-1BB and Bcl-xL in Gastric Mucosa of Patients with Gastric Precancerous Lesions of Qi Deficiency and Blood Stasis Type

作　　者：袁星星 王炳予 杨磊 李丹丹 张雅丽 

机构地区：[1]黑龙江省中医药科学院南岗分院

出　　处：《中医杂志》2017年第13期1130-1134,共5页Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药科学技术研究专项(2016ZX05);黑龙江省科技计划(GC12C110);黑龙江省博士后科研启动基金(LBH-Q13156)

摘　　要：目的观察丹芪祛瘀止痛颗粒治疗气虚血瘀型胃癌前病变患者的临床疗效及可能作用机制。方法将68例气虚血瘀型胃癌前病变患者随机分为治疗组和对照组各34例。治疗组给予丹芪祛瘀止痛颗粒,每次10g,每天3次。对照组给予维酶素片,每次0.8 g,每天3次。两组疗程均为3个月。治疗后评价临床疗效,治疗前后分别对患者中医症状、胃黏膜组织病理进行评分,并检测胃黏膜组织中肿瘤坏死因子受体相关因子1(TRAF1)、淋巴细胞活化诱导受体(4-1BB)及白细胞淋巴瘤/白血病xL(Bcl-xL)的表达。结果治疗组临床疗效总有效率为85.29%,对照组为58.82%,治疗组明显高于对照组(P<0.05)。两组患者治疗后中医症状评分、胃黏膜组织病理评分均较本组治疗前明显下降,且治疗组均明显低于对照组(P<0.05或P<0.01)。治疗后治疗组胃黏膜组织中TRAF1、4-1BB、Bcl-xL表达明显下降,对照组TRAF1表达明显下降,且治疗组TRAF1、4-1BB、Bcl-xL表达均明显低于对照组(P<0.05或P<0.01)。结论丹芪祛瘀止痛颗粒可明显改善气虚血瘀型胃癌前病变患者胃黏膜组织病理情况,其机制可能与下调胃黏膜组织中TRAF1、4-1BB、Bcl-xL表达水平有关。Objective To observe the clinical efficacy and potential mechanism of Danqi Ququ Zhitong Particles（ 丹芪祛瘀止痛颗粒,DQZP） in treating patients with gastric precancerous lesions of Qi deficiency and blood stasis type. Methods Sixty-eight patients with precancerous lesion of Qi deficiency and blood stasis type were randomized into a treatment group and a control group,with 34 cases in each group. The treatment group was given DQZP,with10 g each time and 3 times a day,while the control group was administered Vitacoenzyme Tablets with 0. 8 g each time and 3 times a day. Both groups were treated for 3 months. The clinical efficacy was evaluated after treatment,and the Chinese medicine symptoms and the pathology of gastric mucosa were scored before and after treatment. The expressions of tumor necrosis factor receptor-associated factor 1（ TRAF1）,lymphocyte activation induced receptor（ 4-1BB）and B-cell lymphoma-extra large（ Bcl-xL） were also detected. Results The total effective rate of the treatment group was 85. 29%,significantly higher than 58. 82% of the control group（ P 0. 05）. For both groups,the Chinese symptoms score and the pathology score of the gastric mucosa significantly decreased after treatment,and those of the treatment group were significantly lower than those of the control group（ P 0. 05 or P 0. 01）. After treatment,the expressions of TRAF1,4-1BB,Bcl-xL in the treatment group declined significantly,while in the control group,only TRAF1 expression declined significantly,and the TRAF1,4-1BB,Bcl-xL expressions of the treatment group were significantly lower than those of the control group（ P 0. 05 or P 0. 01）. Conclusion DQZP could improve the pathology condition of the gastric mucosa in patients with precancerous lesions of Qi deficiency and blood stasis type,and the mechanism seems related to down-regulate the expressions of TRAF1,4-1BB and Bcl-xL in gastric mucosa.

关 键 词：慢性萎缩性胃炎 丹芪祛瘀止痛颗粒 胃癌前病变 气虚血瘀 

分 类 号：R259[医药卫生—中西医结合]